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Protein

Zinc finger and SCAN domain-containing protein 20

Gene

Zscan20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri697 – 719C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri918 – 940C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri946 – 968C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri974 – 996C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1002 – 1024C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 20
Alternative name(s):
Zinc finger protein 31
Gene namesi
Name:Zscan20
Synonyms:Zfp31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2679268 Zscan20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003675881 – 1030Zinc finger and SCAN domain-containing protein 20Add BLAST1030

Proteomic databases

PaxDbiB2KFW1
PeptideAtlasiB2KFW1
PRIDEiB2KFW1

PTM databases

iPTMnetiB2KFW1
PhosphoSitePlusiB2KFW1

Expressioni

Gene expression databases

BgeeiENSMUSG00000061894
ExpressionAtlasiB2KFW1 baseline and differential
GenevisibleiB2KFW1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095487

Structurei

3D structure databases

ProteinModelPortaliB2KFW1
SMRiB2KFW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri697 – 719C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri862 – 884C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri890 – 912C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri918 – 940C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri946 – 968C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri974 – 996C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1002 – 1024C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOGENOMiHOG000234618
HOVERGENiHBG018163
InParanoidiB2KFW1
KOiK09230
OMAiIDHQGLY
OrthoDBiEOG091G02KC
PhylomeDBiB2KFW1
TreeFamiTF337082

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001005 SANT/Myb
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2KFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAVASPPPE PEDLLIVKLE EDSWGSDSRP EKESHSPVPG PEVSRRCFRQ
60 70 80 90 100
FRYRDAAGPH EAFSQLWALC CRWLRPELRL KEQILELLVL EQFLSILPRE
110 120 130 140 150
VQTWVQARHP ESGEEAVALV EDWHREAWAA GQQGLELCSE DSRSFEAVQE
160 170 180 190 200
FQRFQLQPVT HGSEGQPRKQ WVENARPDLS KMPPESLKES AVLTPQAPTV
210 220 230 240 250
PKMASIGDWE VAGKSQETPS PSRQAKKEPC QDPAGGDRGD SACLGVPASK
260 270 280 290 300
PSATSQQEQG PEIWGLSLIN SGNGSAADDS LDSAQDKPVQ AVAQADSRAW
310 320 330 340 350
GEPCQWGAED MKVSGVHWGY EETKTFLAIL SESPFSEKLQ TCHQNRQVYR
360 370 380 390 400
AIAERLRARG FLRTLEQCRY RVKNLLRNYR KAKNSHPPGT CPFYEELEAL
410 420 430 440 450
VRARTAIRRT SGGPGEAVAL PRLGDSDTEM DDQDEGSWEP EETVEDCSGS
460 470 480 490 500
GLAAEESLQG PRIAGGPALL QSRIAGVHWG FEETKVFLAI LSESPFAEKL
510 520 530 540 550
RTCHQNSQIY RAIAERLRAL GFLRTLEQCR YRFKNLLRSY RKAKSSCPPG
560 570 580 590 600
TCPFYEEMDS LMRARTVIRA VEMVGEATGL PGSGQSSTEA DDQEAWGEME
610 620 630 640 650
DEDAVRLLTP DSQPADAGFE LKREEEDQIS EQDVLGDLPG ALSRYTTKAV
660 670 680 690 700
CQPCDWGEDH VNGNEGEWRN TWEECSSEED LEKLIDHQGL YLTEKPYGCD
710 720 730 740 750
TRAKSFSRKV HFFAPQRTHS SEKPYKCLGS GKSFSDRANL STHQRIHIGE
760 770 780 790 800
KPYRCLECGK SFNDPSNLIT HQRTHTGEKP YKCGLCWKSF NQSSNLLKHQ
810 820 830 840 850
RVHLGGPPNQ RDEPGENFGQ SLSYSAHWRR NSTQEGPKEP QNISMGADSP
860 870 880 890 900
GACHPNSGEK LYSCPECGRC FSKSSALTSH QRIHSGEKPY ECAVCGKSFS
910 920 930 940 950
KSSSLANHRR THTGEKPHKC ADCGKCFSER SKLITHQRVH TGEKPYECPE
960 970 980 990 1000
CGKFFRDRSN LITHQRIHTG EKPYKCRECG KCFNQSSSLI IHQRIHTGEK
1010 1020 1030
PYKCTECGKD FNNSSHFSAH RRTHAGGKAL
Length:1,030
Mass (Da):115,379
Last modified:March 24, 2009 - v2
Checksum:i287C0AA0ECE6BE07
GO
Isoform 2 (identifier: B2KFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-429: Missing.

Show »
Length:601
Mass (Da):67,542
Checksum:i90B65BF55B117C08
GO

Sequence cautioni

The sequence AAH76602 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE25797 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → C in CAQ51752 (PubMed:16141072).Curated1
Sequence conflicti223R → S in BAE25797 (PubMed:16141072).Curated1
Sequence conflicti627D → G in BAE25797 (PubMed:16141072).Curated1
Sequence conflicti857S → P in BAE25797 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367401 – 429Missing in isoform 2. 2 PublicationsAdd BLAST429

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047820 mRNA Translation: BAC33164.1
AK144249 mRNA Translation: BAE25797.1 Different initiation.
AK153688 mRNA Translation: BAE32146.1
AK153845 mRNA Translation: BAE32209.1
AL611969 Genomic DNA Translation: CAM23047.1
CU210837 Genomic DNA Translation: CAQ51752.1
BC065079 mRNA Translation: AAH65079.1
BC076602 mRNA Translation: AAH76602.1 Different initiation.
CCDSiCCDS18672.2 [B2KFW1-1]
RefSeqiNP_808426.2, NM_177758.4 [B2KFW1-1]
XP_006503194.1, XM_006503131.2 [B2KFW1-1]
XP_006503196.1, XM_006503133.2 [B2KFW1-1]
XP_006503197.1, XM_006503134.2 [B2KFW1-1]
XP_011238844.1, XM_011240542.2 [B2KFW1-1]
XP_011238845.1, XM_011240543.2 [B2KFW1-1]
XP_011238849.1, XM_011240547.2 [B2KFW1-2]
UniGeneiMm.153291

Genome annotation databases

EnsembliENSMUST00000097877; ENSMUSP00000095487; ENSMUSG00000061894 [B2KFW1-1]
GeneIDi269585
KEGGimmu:269585
UCSCiuc008uvd.2 mouse [B2KFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZSC20_MOUSE
AccessioniPrimary (citable) accession number: B2KFW1
Secondary accession number(s): B1AS93
, Q3UNF0, Q6DFW6, Q8BJ07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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