Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and SCAN domain-containing protein 20

Gene

Zscan20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri697 – 71923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri753 – 77523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri781 – 80323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri862 – 88423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri890 – 91223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri918 – 94023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri946 – 96823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri974 – 99623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1002 – 102423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 20
Alternative name(s):
Zinc finger protein 31
Gene namesi
Name:Zscan20
Synonyms:Zfp31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2679268. Zscan20.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10301030Zinc finger and SCAN domain-containing protein 20PRO_0000367588Add
BLAST

Proteomic databases

PaxDbiB2KFW1.
PeptideAtlasiB2KFW1.
PRIDEiB2KFW1.

PTM databases

iPTMnetiB2KFW1.

Expressioni

Gene expression databases

BgeeiB2KFW1.
ExpressionAtlasiB2KFW1. baseline and differential.
GenevisibleiB2KFW1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095487.

Structurei

3D structure databases

ProteinModelPortaliB2KFW1.
SMRiB2KFW1. Positions 39-126, 722-829, 859-1030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12783SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri697 – 71923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri753 – 77523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri781 – 80323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri862 – 88423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri890 – 91223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri918 – 94023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri946 – 96823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri974 – 99623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1002 – 102423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiB2KFW1.
KOiK09230.
OMAiPGALSKC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiB2KFW1.
TreeFamiTF337082.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR001005. SANT/Myb.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2KFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAVASPPPE PEDLLIVKLE EDSWGSDSRP EKESHSPVPG PEVSRRCFRQ
60 70 80 90 100
FRYRDAAGPH EAFSQLWALC CRWLRPELRL KEQILELLVL EQFLSILPRE
110 120 130 140 150
VQTWVQARHP ESGEEAVALV EDWHREAWAA GQQGLELCSE DSRSFEAVQE
160 170 180 190 200
FQRFQLQPVT HGSEGQPRKQ WVENARPDLS KMPPESLKES AVLTPQAPTV
210 220 230 240 250
PKMASIGDWE VAGKSQETPS PSRQAKKEPC QDPAGGDRGD SACLGVPASK
260 270 280 290 300
PSATSQQEQG PEIWGLSLIN SGNGSAADDS LDSAQDKPVQ AVAQADSRAW
310 320 330 340 350
GEPCQWGAED MKVSGVHWGY EETKTFLAIL SESPFSEKLQ TCHQNRQVYR
360 370 380 390 400
AIAERLRARG FLRTLEQCRY RVKNLLRNYR KAKNSHPPGT CPFYEELEAL
410 420 430 440 450
VRARTAIRRT SGGPGEAVAL PRLGDSDTEM DDQDEGSWEP EETVEDCSGS
460 470 480 490 500
GLAAEESLQG PRIAGGPALL QSRIAGVHWG FEETKVFLAI LSESPFAEKL
510 520 530 540 550
RTCHQNSQIY RAIAERLRAL GFLRTLEQCR YRFKNLLRSY RKAKSSCPPG
560 570 580 590 600
TCPFYEEMDS LMRARTVIRA VEMVGEATGL PGSGQSSTEA DDQEAWGEME
610 620 630 640 650
DEDAVRLLTP DSQPADAGFE LKREEEDQIS EQDVLGDLPG ALSRYTTKAV
660 670 680 690 700
CQPCDWGEDH VNGNEGEWRN TWEECSSEED LEKLIDHQGL YLTEKPYGCD
710 720 730 740 750
TRAKSFSRKV HFFAPQRTHS SEKPYKCLGS GKSFSDRANL STHQRIHIGE
760 770 780 790 800
KPYRCLECGK SFNDPSNLIT HQRTHTGEKP YKCGLCWKSF NQSSNLLKHQ
810 820 830 840 850
RVHLGGPPNQ RDEPGENFGQ SLSYSAHWRR NSTQEGPKEP QNISMGADSP
860 870 880 890 900
GACHPNSGEK LYSCPECGRC FSKSSALTSH QRIHSGEKPY ECAVCGKSFS
910 920 930 940 950
KSSSLANHRR THTGEKPHKC ADCGKCFSER SKLITHQRVH TGEKPYECPE
960 970 980 990 1000
CGKFFRDRSN LITHQRIHTG EKPYKCRECG KCFNQSSSLI IHQRIHTGEK
1010 1020 1030
PYKCTECGKD FNNSSHFSAH RRTHAGGKAL
Length:1,030
Mass (Da):115,379
Last modified:March 24, 2009 - v2
Checksum:i287C0AA0ECE6BE07
GO
Isoform 2 (identifier: B2KFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-429: Missing.

Show »
Length:601
Mass (Da):67,542
Checksum:i90B65BF55B117C08
GO

Sequence cautioni

The sequence AAH76602.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE25797.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761R → C in CAQ51752 (PubMed:16141072).Curated
Sequence conflicti223 – 2231R → S in BAE25797 (PubMed:16141072).Curated
Sequence conflicti627 – 6271D → G in BAE25797 (PubMed:16141072).Curated
Sequence conflicti857 – 8571S → P in BAE25797 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 429429Missing in isoform 2. 2 PublicationsVSP_036740Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047820 mRNA. Translation: BAC33164.1.
AK144249 mRNA. Translation: BAE25797.1. Different initiation.
AK153688 mRNA. Translation: BAE32146.1.
AK153845 mRNA. Translation: BAE32209.1.
AL611969 Genomic DNA. Translation: CAM23047.1.
CU210837 Genomic DNA. Translation: CAQ51752.1.
BC065079 mRNA. Translation: AAH65079.1.
BC076602 mRNA. Translation: AAH76602.1. Different initiation.
CCDSiCCDS18672.2. [B2KFW1-1]
RefSeqiNP_808426.2. NM_177758.4. [B2KFW1-1]
XP_006503194.1. XM_006503131.2. [B2KFW1-1]
XP_006503196.1. XM_006503133.2. [B2KFW1-1]
XP_006503197.1. XM_006503134.2. [B2KFW1-1]
XP_006537063.1. XM_006537000.2. [B2KFW1-2]
XP_011238844.1. XM_011240542.1. [B2KFW1-1]
XP_011238845.1. XM_011240543.1. [B2KFW1-1]
XP_011238849.1. XM_011240547.1. [B2KFW1-2]
UniGeneiMm.153291.

Genome annotation databases

EnsembliENSMUST00000097877; ENSMUSP00000095487; ENSMUSG00000061894. [B2KFW1-1]
GeneIDi269585.
KEGGimmu:269585.
UCSCiuc008uvd.2. mouse. [B2KFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047820 mRNA. Translation: BAC33164.1.
AK144249 mRNA. Translation: BAE25797.1. Different initiation.
AK153688 mRNA. Translation: BAE32146.1.
AK153845 mRNA. Translation: BAE32209.1.
AL611969 Genomic DNA. Translation: CAM23047.1.
CU210837 Genomic DNA. Translation: CAQ51752.1.
BC065079 mRNA. Translation: AAH65079.1.
BC076602 mRNA. Translation: AAH76602.1. Different initiation.
CCDSiCCDS18672.2. [B2KFW1-1]
RefSeqiNP_808426.2. NM_177758.4. [B2KFW1-1]
XP_006503194.1. XM_006503131.2. [B2KFW1-1]
XP_006503196.1. XM_006503133.2. [B2KFW1-1]
XP_006503197.1. XM_006503134.2. [B2KFW1-1]
XP_006537063.1. XM_006537000.2. [B2KFW1-2]
XP_011238844.1. XM_011240542.1. [B2KFW1-1]
XP_011238845.1. XM_011240543.1. [B2KFW1-1]
XP_011238849.1. XM_011240547.1. [B2KFW1-2]
UniGeneiMm.153291.

3D structure databases

ProteinModelPortaliB2KFW1.
SMRiB2KFW1. Positions 39-126, 722-829, 859-1030.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095487.

PTM databases

iPTMnetiB2KFW1.

Proteomic databases

PaxDbiB2KFW1.
PeptideAtlasiB2KFW1.
PRIDEiB2KFW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097877; ENSMUSP00000095487; ENSMUSG00000061894. [B2KFW1-1]
GeneIDi269585.
KEGGimmu:269585.
UCSCiuc008uvd.2. mouse. [B2KFW1-1]

Organism-specific databases

CTDi7579.
MGIiMGI:2679268. Zscan20.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiB2KFW1.
KOiK09230.
OMAiPGALSKC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiB2KFW1.
TreeFamiTF337082.

Miscellaneous databases

PROiB2KFW1.
SOURCEiSearch...

Gene expression databases

BgeeiB2KFW1.
ExpressionAtlasiB2KFW1. baseline and differential.
GenevisibleiB2KFW1. MM.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR001005. SANT/Myb.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Head, Lymph node and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiZSC20_MOUSE
AccessioniPrimary (citable) accession number: B2KFW1
Secondary accession number(s): B1AS93
, Q3UNF0, Q6DFW6, Q8BJ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: July 6, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.