B2KE93 (UPPP_ELUMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Emin_1289

Organism

Elusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP]

Taxonomic identifier

445932 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Elusimicrobia › Elusimicrobia › Elusimicrobiales › Elusimicrobiaceae › Elusimicrobium › Elusimicrobium minutum

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197363
Regions
	Transmembrane	14 – 34	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B2KE93 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 009778AE7B62B80B	FASTA	258	28,109
	10 20 30 40 50 60 MTSVNAVLLG LVQAAGEFLP ISSSAHLVLM PWLLGMEYQG LTYDIFLHLA TLIAVLIYFR 70 80 90 100 110 120 KEWFTIIKDG LTKPKTEEGK ILWLLVLGTI PAAICGVLFE DWIETVFRSP FVIAAALIVF 130 140 150 160 170 180 AVILHLADKR AGQKDVALNV KTVLIIGCAQ ALALMPGVSR SGITITAALF LGFSRAESAK 190 200 210 220 230 240 ISFLLSTPII AGAAVLKLKD INPADINAAF IAGFLTAAIF GWLFIKFLMN YVQKHNFNIF 250 VVYRIALGVI IIITALMK

References

[1]

"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)." Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A. Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pei191.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001055 Genomic DNA. Translation: ACC98839.1.
RefSeq	YP_001876176.1. NC_010644.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	445932.Emin_1289.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACC98839; ACC98839; Emin_1289.
GeneID	6262856.
KEGG	emi:Emin_1289.
PATRIC	21849814. VBIEluMin86178_1332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HMMWALI.
Enzyme and pathway databases
BioCyc	EMIN445932:GHM0-1325-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_ELUMP

Accession

Primary (citable) accession number: B2KE93

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program