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B2KE93 (UPPP_ELUMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Emin_1289
OrganismElusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP]
Taxonomic identifier445932 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197363

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane237 – 25721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2KE93 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 009778AE7B62B80B

FASTA25828,109
        10         20         30         40         50         60 
MTSVNAVLLG LVQAAGEFLP ISSSAHLVLM PWLLGMEYQG LTYDIFLHLA TLIAVLIYFR 

        70         80         90        100        110        120 
KEWFTIIKDG LTKPKTEEGK ILWLLVLGTI PAAICGVLFE DWIETVFRSP FVIAAALIVF 

       130        140        150        160        170        180 
AVILHLADKR AGQKDVALNV KTVLIIGCAQ ALALMPGVSR SGITITAALF LGFSRAESAK 

       190        200        210        220        230        240 
ISFLLSTPII AGAAVLKLKD INPADINAAF IAGFLTAAIF GWLFIKFLMN YVQKHNFNIF 

       250 
VVYRIALGVI IIITALMK 

« Hide

References

[1]"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pei191.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001055 Genomic DNA. Translation: ACC98839.1.
RefSeqYP_001876176.1. NC_010644.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445932.Emin_1289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC98839; ACC98839; Emin_1289.
GeneID6262856.
KEGGemi:Emin_1289.
PATRIC21849814. VBIEluMin86178_1332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAMEQINIG.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycEMIN445932:GHM0-1325-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ELUMP
AccessionPrimary (citable) accession number: B2KE93
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families