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B2KE57

- B2KE57_ELUMP

UniProt

B2KE57 - B2KE57_ELUMP

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Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

Emin_1253

Organism
Elusimicrobium minutum (strain Pei191)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
  3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciEMIN445932:GHM0-1289-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Gene namesi
Ordered Locus Names:Emin_1253Imported
OrganismiElusimicrobium minutum (strain Pei191)Imported
Taxonomic identifieri445932 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
ProteomesiUP000001029: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi445932.Emin_1253.

Structurei

3D structure databases

ProteinModelPortaliB2KE57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0770.
HOGENOMiHOG000268120.
KOiK01929.
OMAiVVNDTTE.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

B2KE57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYLNLTLGSF AKIVDGRIIQ GNPLMPFNAF ITDSRKLTKG DIFWALKGEK
60 70 80 90 100
FDGNTFLQNA VDAGASALVA DKFFADKIDL KNTALVEVEN TLTALQTLAA
110 120 130 140 150
YHRRRSDLKV VAITGSNGKS TTKQMLLSIC KTSGPARANM GNLNNQFGLP
160 170 180 190 200
FSLLEIDSKD KFGVFELGAS KKGDILEIGK PTLPDVAIIT NVSAAHLQFF
210 220 230 240 250
KDLKTVYETK TELIDCLNFG GILVFNSDDA MLKKLKTEYK GKAISFGFKS
260 270 280 290 300
GADLQIKNKK NLEFVYKGEV FSFDLQFEKH NKLNAAAAAA GAIALGLYKD
310 320 330 340 350
NIEKGLAAYE AMPMRMEERK IGNVDFILDC YNANPASMKN AITLLAKRKA
360 370 380 390 400
GPRVAVLGDM KELGNCSAKY HAHLAKILIG KQIDYIFLSG PEMAAAAEAL
410 420 430 440 450
KTKNPAAKLK YSLEYKDWAQ DLKEVLKNGG TCLIKASRSM NYEKILDCLK
Length:450
Mass (Da):49,366
Last modified:June 10, 2008 - v1
Checksum:i1795587F1ACCE68E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001055 Genomic DNA. Translation: ACC98803.1.
RefSeqiWP_012415418.1. NC_010644.1.
YP_001876140.1. NC_010644.1.

Genome annotation databases

EnsemblBacteriaiACC98803; ACC98803; Emin_1253.
GeneIDi6263926.
KEGGiemi:Emin_1253.
PATRICi21849740. VBIEluMin86178_1295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001055 Genomic DNA. Translation: ACC98803.1 .
RefSeqi WP_012415418.1. NC_010644.1.
YP_001876140.1. NC_010644.1.

3D structure databases

ProteinModelPortali B2KE57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445932.Emin_1253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC98803 ; ACC98803 ; Emin_1253 .
GeneIDi 6263926.
KEGGi emi:Emin_1253.
PATRICi 21849740. VBIEluMin86178_1295.

Phylogenomic databases

eggNOGi COG0770.
HOGENOMi HOG000268120.
KOi K01929.
OMAi VVNDTTE.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci EMIN445932:GHM0-1289-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view ]
PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01143. murF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
    Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
    Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pei191Imported.

Entry informationi

Entry nameiB2KE57_ELUMP
AccessioniPrimary (citable) accession number: B2KE57
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3