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B2KE57 (B2KE57_ELUMP) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136

EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:Emin_1253 EMBL ACC98803.1
OrganismElusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP] EMBL ACC98803.1
Taxonomic identifier445932 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
B2KE57 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 1795587F1ACCE68E

FASTA45049,366
        10         20         30         40         50         60 
MYLNLTLGSF AKIVDGRIIQ GNPLMPFNAF ITDSRKLTKG DIFWALKGEK FDGNTFLQNA 

        70         80         90        100        110        120 
VDAGASALVA DKFFADKIDL KNTALVEVEN TLTALQTLAA YHRRRSDLKV VAITGSNGKS 

       130        140        150        160        170        180 
TTKQMLLSIC KTSGPARANM GNLNNQFGLP FSLLEIDSKD KFGVFELGAS KKGDILEIGK 

       190        200        210        220        230        240 
PTLPDVAIIT NVSAAHLQFF KDLKTVYETK TELIDCLNFG GILVFNSDDA MLKKLKTEYK 

       250        260        270        280        290        300 
GKAISFGFKS GADLQIKNKK NLEFVYKGEV FSFDLQFEKH NKLNAAAAAA GAIALGLYKD 

       310        320        330        340        350        360 
NIEKGLAAYE AMPMRMEERK IGNVDFILDC YNANPASMKN AITLLAKRKA GPRVAVLGDM 

       370        380        390        400        410        420 
KELGNCSAKY HAHLAKILIG KQIDYIFLSG PEMAAAAEAL KTKNPAAKLK YSLEYKDWAQ 

       430        440        450 
DLKEVLKNGG TCLIKASRSM NYEKILDCLK 

« Hide

References

[1]"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
Herlemann D.P., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pei191 EMBL ACC98803.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001055 Genomic DNA. Translation: ACC98803.1.
RefSeqYP_001876140.1. NC_010644.1.

3D structure databases

ProteinModelPortalB2KE57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445932.Emin_1253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC98803; ACC98803; Emin_1253.
GeneID6263926.
KEGGemi:Emin_1253.
PATRIC21849740. VBIEluMin86178_1295.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268120.
KOK01929.
OMARTWEVAD.
OrthoDBEOG6PKFCR.

Enzyme and pathway databases

BioCycEMIN445932:GHM0-1289-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2KE57_ELUMP
AccessionPrimary (citable) accession number: B2KE57
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)