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B2KE57

- B2KE57_ELUMP

UniProt

B2KE57 - B2KE57_ELUMP

Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

Emin_1253

Organism
Elusimicrobium minutum (strain Pei191)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation
    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
    3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEMIN445932:GHM0-1289-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
    Gene namesi
    Ordered Locus Names:Emin_1253Imported
    OrganismiElusimicrobium minutum (strain Pei191)Imported
    Taxonomic identifieri445932 [NCBI]
    Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
    ProteomesiUP000001029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Interactioni

    Protein-protein interaction databases

    STRINGi445932.Emin_1253.

    Structurei

    3D structure databases

    ProteinModelPortaliB2KE57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0770.
    HOGENOMiHOG000268120.
    KOiK01929.
    OMAiVVNDTTE.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view]
    PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsiTIGR01143. murF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2KE57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLNLTLGSF AKIVDGRIIQ GNPLMPFNAF ITDSRKLTKG DIFWALKGEK    50
    FDGNTFLQNA VDAGASALVA DKFFADKIDL KNTALVEVEN TLTALQTLAA 100
    YHRRRSDLKV VAITGSNGKS TTKQMLLSIC KTSGPARANM GNLNNQFGLP 150
    FSLLEIDSKD KFGVFELGAS KKGDILEIGK PTLPDVAIIT NVSAAHLQFF 200
    KDLKTVYETK TELIDCLNFG GILVFNSDDA MLKKLKTEYK GKAISFGFKS 250
    GADLQIKNKK NLEFVYKGEV FSFDLQFEKH NKLNAAAAAA GAIALGLYKD 300
    NIEKGLAAYE AMPMRMEERK IGNVDFILDC YNANPASMKN AITLLAKRKA 350
    GPRVAVLGDM KELGNCSAKY HAHLAKILIG KQIDYIFLSG PEMAAAAEAL 400
    KTKNPAAKLK YSLEYKDWAQ DLKEVLKNGG TCLIKASRSM NYEKILDCLK 450
    Length:450
    Mass (Da):49,366
    Last modified:June 10, 2008 - v1
    Checksum:i1795587F1ACCE68E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC98803.1.
    RefSeqiYP_001876140.1. NC_010644.1.

    Genome annotation databases

    EnsemblBacteriaiACC98803; ACC98803; Emin_1253.
    GeneIDi6263926.
    KEGGiemi:Emin_1253.
    PATRICi21849740. VBIEluMin86178_1295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC98803.1 .
    RefSeqi YP_001876140.1. NC_010644.1.

    3D structure databases

    ProteinModelPortali B2KE57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 445932.Emin_1253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC98803 ; ACC98803 ; Emin_1253 .
    GeneIDi 6263926.
    KEGGi emi:Emin_1253.
    PATRICi 21849740. VBIEluMin86178_1295.

    Phylogenomic databases

    eggNOGi COG0770.
    HOGENOMi HOG000268120.
    KOi K01929.
    OMAi VVNDTTE.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci EMIN445932:GHM0-1289-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view ]
    PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsi TIGR01143. murF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
      Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
      Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pei191Imported.

    Entry informationi

    Entry nameiB2KE57_ELUMP
    AccessioniPrimary (citable) accession number: B2KE57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3