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B2KDX2

- PNP_ELUMP

UniProt

B2KDX2 - PNP_ELUMP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Emin_1167
Organism
Elusimicrobium minutum (strain Pei191)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901Magnesium By similarity
Metal bindingi496 – 4961Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciEMIN445932:GHM0-1202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Emin_1167
OrganismiElusimicrobium minutum (strain Pei191)
Taxonomic identifieri445932 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
ProteomesiUP000001029: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000381886Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi445932.Emin_1167.

Structurei

3D structure databases

ProteinModelPortaliB2KDX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini558 – 61760KHAdd
BLAST
Domaini627 – 69569S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGRMHIMD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2KDX2-1 [UniParc]FASTAAdd to Basket

« Hide

MSNINKTTQD VIVGDKTLSL ETGWVAKQAD GSVIARMGDT MVLATAVSDK    50
VQKPGISDFV PLTVNYKERT YAAGKIPGGF FKRESRASKK ETLASRIIDR 100
SLRPLFPSGY TCETNVTAMV LSADGVYDTE VLAVMASSTA LIISSIPFTT 150
PVAAVRIGRL NGNFIVNPTL EEQKSCDMDL IISGSLEGML MVEGGAKEVS 200
EEDVIKALET AKPAIDILCK AQLELKEKAG KEKFSFQAET VPQDVVDLGN 250
NKYRAEVANI LNAFYDKQTR DVKIAELKAA FAEEIKEAHG DNASTFAGIT 300
MENLSYEESR KLVLEKGVRV DGRKTDEIRQ LNSITGLLPR AHGSALFTRG 350
QTQGLVVTTL GTSGDAQLVE SLEESYDETF MLHYNFPGFS TGECKPDRAP 400
GRREIGHGEL ARRALLPLIP DADKFPYTIR VVSDIMESNG SSSMASVCGG 450
SLSLFDAGVP MKAACSGIAM GLIKEGDKYA VLSDIMGLED HLGDMDFKLT 500
GSRNGITAFQ MDVKLAGGIS IEILKEAVAQ ATKGRMHIMD HMDSVLPEPR 550
KDVSKFAPVI YTMRIPQDKI GALIGPGGKN IKRITETTDT KIDINDDGVV 600
QIAAVNGDKL AMAKAEIELL TAEVELNKIY KGKVVSIQPF GAFVELIPGK 650
DGLLHISEID KKRINKVEDV LKMGDIVEVK VVEIDNNGKV RLSRKVLL 698
Length:698
Mass (Da):75,647
Last modified:June 10, 2008 - v1
Checksum:i1BD2A41D9AB9E304
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001055 Genomic DNA. Translation: ACC98718.1.
RefSeqiYP_001876055.1. NC_010644.1.

Genome annotation databases

EnsemblBacteriaiACC98718; ACC98718; Emin_1167.
GeneIDi6262966.
KEGGiemi:Emin_1167.
PATRICi21849566. VBIEluMin86178_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001055 Genomic DNA. Translation: ACC98718.1 .
RefSeqi YP_001876055.1. NC_010644.1.

3D structure databases

ProteinModelPortali B2KDX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445932.Emin_1167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC98718 ; ACC98718 ; Emin_1167 .
GeneIDi 6262966.
KEGGi emi:Emin_1167.
PATRICi 21849566. VBIEluMin86178_1209.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GRMHIMD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci EMIN445932:GHM0-1202-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
    Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
    Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pei191.

Entry informationi

Entry nameiPNP_ELUMP
AccessioniPrimary (citable) accession number: B2KDX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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