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B2KDK9

- FTHS_ELUMP

UniProt

B2KDK9 - FTHS_ELUMP

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Elusimicrobium minutum (strain Pei191)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEMIN445932:GHM0-1086-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Emin_1052
OrganismiElusimicrobium minutum (strain Pei191)
Taxonomic identifieri445932 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
ProteomesiUP000001029: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146682Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi445932.Emin_1052.

Structurei

3D structure databases

ProteinModelPortaliB2KDK9.
SMRiB2KDK9. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2KDK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEIAQR AKVWPIAKVA VKLGIKKSQI ELYGHYKAKL SFDCIKKLQK
60 70 80 90 100
KPDGNLILVT AISPTAAGEG KSTTTVGLAQ ALAKIGKKAI VALREPSLGP
110 120 130 140 150
CMGIKGGAAG GGYSQVVPME DINLHFTGDM HAITAANNLL SAIIDNHIHQ
160 170 180 190 200
GNELGIDERR IVWHRVVDIN DRALRNIVVA LGGKGNGFPR EDSFDITVAS
210 220 230 240 250
EVMAILCLSE SLADLKKRLS KVIVGYNFAD KPVTAGMLKA EGAMAALLKD
260 270 280 290 300
AIKPNLVQTL ENVPAIIHGG PFANIAHGCN SVIATKTALK LADYIVTEAG
310 320 330 340 350
FGADLGAEKF FNIKCRYAGL TPKVAIIVAT VRALKMHGGV SKDKLTHLDK
360 370 380 390 400
QAVIRGLVNL DKHIENVKKF GVPPVVAINI FSGDSKEEIA AVKAHCKKIG
410 420 430 440 450
VPVELSDVFA KGGEGGIQLA KKVVDIISKN KSKFRFTYES EDSLEEKTKK
460 470 480 490 500
IVKNIYGAKD VFFDKKALDS IKKYEAMGFG NIPVCMAKTQ YSFSDNPKLY
510 520 530 540 550
GRPEGFTIEV REARISAGAG FVVMLTGNIM TMPGLPKFPA AEKIDISSEG

VIKGLS
Length:556
Mass (Da):59,643
Last modified:June 10, 2008 - v1
Checksum:i1F7C40552C960A33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001055 Genomic DNA. Translation: ACC98605.1.
RefSeqiWP_012415220.1. NC_010644.1.
YP_001875942.1. NC_010644.1.

Genome annotation databases

EnsemblBacteriaiACC98605; ACC98605; Emin_1052.
GeneIDi6263906.
KEGGiemi:Emin_1052.
PATRICi21849330. VBIEluMin86178_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001055 Genomic DNA. Translation: ACC98605.1 .
RefSeqi WP_012415220.1. NC_010644.1.
YP_001875942.1. NC_010644.1.

3D structure databases

ProteinModelPortali B2KDK9.
SMRi B2KDK9. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445932.Emin_1052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC98605 ; ACC98605 ; Emin_1052 .
GeneIDi 6263906.
KEGGi emi:Emin_1052.
PATRICi 21849330. VBIEluMin86178_1092.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci EMIN445932:GHM0-1086-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
    Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
    Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pei191.

Entry informationi

Entry nameiFTHS_ELUMP
AccessioniPrimary (citable) accession number: B2KDK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3