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B2KDK9

- FTHS_ELUMP

UniProt

B2KDK9 - FTHS_ELUMP

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Elusimicrobium minutum (strain Pei191)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEMIN445932:GHM0-1086-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Emin_1052
    OrganismiElusimicrobium minutum (strain Pei191)
    Taxonomic identifieri445932 [NCBI]
    Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
    ProteomesiUP000001029: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146682Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi445932.Emin_1052.

    Structurei

    3D structure databases

    ProteinModelPortaliB2KDK9.
    SMRiB2KDK9. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2KDK9-1 [UniParc]FASTAAdd to Basket

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    MLSDIEIAQR AKVWPIAKVA VKLGIKKSQI ELYGHYKAKL SFDCIKKLQK    50
    KPDGNLILVT AISPTAAGEG KSTTTVGLAQ ALAKIGKKAI VALREPSLGP 100
    CMGIKGGAAG GGYSQVVPME DINLHFTGDM HAITAANNLL SAIIDNHIHQ 150
    GNELGIDERR IVWHRVVDIN DRALRNIVVA LGGKGNGFPR EDSFDITVAS 200
    EVMAILCLSE SLADLKKRLS KVIVGYNFAD KPVTAGMLKA EGAMAALLKD 250
    AIKPNLVQTL ENVPAIIHGG PFANIAHGCN SVIATKTALK LADYIVTEAG 300
    FGADLGAEKF FNIKCRYAGL TPKVAIIVAT VRALKMHGGV SKDKLTHLDK 350
    QAVIRGLVNL DKHIENVKKF GVPPVVAINI FSGDSKEEIA AVKAHCKKIG 400
    VPVELSDVFA KGGEGGIQLA KKVVDIISKN KSKFRFTYES EDSLEEKTKK 450
    IVKNIYGAKD VFFDKKALDS IKKYEAMGFG NIPVCMAKTQ YSFSDNPKLY 500
    GRPEGFTIEV REARISAGAG FVVMLTGNIM TMPGLPKFPA AEKIDISSEG 550
    VIKGLS 556
    Length:556
    Mass (Da):59,643
    Last modified:June 10, 2008 - v1
    Checksum:i1F7C40552C960A33
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC98605.1.
    RefSeqiWP_012415220.1. NC_010644.1.
    YP_001875942.1. NC_010644.1.

    Genome annotation databases

    EnsemblBacteriaiACC98605; ACC98605; Emin_1052.
    GeneIDi6263906.
    KEGGiemi:Emin_1052.
    PATRICi21849330. VBIEluMin86178_1092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC98605.1 .
    RefSeqi WP_012415220.1. NC_010644.1.
    YP_001875942.1. NC_010644.1.

    3D structure databases

    ProteinModelPortali B2KDK9.
    SMRi B2KDK9. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 445932.Emin_1052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC98605 ; ACC98605 ; Emin_1052 .
    GeneIDi 6263906.
    KEGGi emi:Emin_1052.
    PATRICi 21849330. VBIEluMin86178_1092.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci EMIN445932:GHM0-1086-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
      Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
      Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pei191.

    Entry informationi

    Entry nameiFTHS_ELUMP
    AccessioniPrimary (citable) accession number: B2KDK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3