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B2KDK9 (FTHS_ELUMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Emin_1052
OrganismElusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP]
Taxonomic identifier445932 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146682

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2KDK9 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 1F7C40552C960A33

FASTA55659,643
        10         20         30         40         50         60 
MLSDIEIAQR AKVWPIAKVA VKLGIKKSQI ELYGHYKAKL SFDCIKKLQK KPDGNLILVT 

        70         80         90        100        110        120 
AISPTAAGEG KSTTTVGLAQ ALAKIGKKAI VALREPSLGP CMGIKGGAAG GGYSQVVPME 

       130        140        150        160        170        180 
DINLHFTGDM HAITAANNLL SAIIDNHIHQ GNELGIDERR IVWHRVVDIN DRALRNIVVA 

       190        200        210        220        230        240 
LGGKGNGFPR EDSFDITVAS EVMAILCLSE SLADLKKRLS KVIVGYNFAD KPVTAGMLKA 

       250        260        270        280        290        300 
EGAMAALLKD AIKPNLVQTL ENVPAIIHGG PFANIAHGCN SVIATKTALK LADYIVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FNIKCRYAGL TPKVAIIVAT VRALKMHGGV SKDKLTHLDK QAVIRGLVNL 

       370        380        390        400        410        420 
DKHIENVKKF GVPPVVAINI FSGDSKEEIA AVKAHCKKIG VPVELSDVFA KGGEGGIQLA 

       430        440        450        460        470        480 
KKVVDIISKN KSKFRFTYES EDSLEEKTKK IVKNIYGAKD VFFDKKALDS IKKYEAMGFG 

       490        500        510        520        530        540 
NIPVCMAKTQ YSFSDNPKLY GRPEGFTIEV REARISAGAG FVVMLTGNIM TMPGLPKFPA 

       550 
AEKIDISSEG VIKGLS 

« Hide

References

[1]"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pei191.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001055 Genomic DNA. Translation: ACC98605.1.
RefSeqYP_001875942.1. NC_010644.1.

3D structure databases

ProteinModelPortalB2KDK9.
SMRB2KDK9. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445932.Emin_1052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC98605; ACC98605; Emin_1052.
GeneID6263906.
KEGGemi:Emin_1052.
PATRIC21849330. VBIEluMin86178_1092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycEMIN445932:GHM0-1086-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ELUMP
AccessionPrimary (citable) accession number: B2KDK9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways