B2KCM6 (HIS4_ELUMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	Emin_0717

Organism

Elusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP]

Taxonomic identifier

445932 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Elusimicrobia › Elusimicrobia › Elusimicrobiales › Elusimicrobiaceae › Elusimicrobium › Elusimicrobium minutum

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01014.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_1000135116
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	130	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2KCM6 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: C8FA1D7ECCAD20D1	FASTA	240	26,258
	10 20 30 40 50 60 MIIFPAIDIL DGKCVRLFKG DFNKTTVYEN DPVKTAKDFE SQGSKYLHIV DLDGAKNPLN 70 80 90 100 110 120 RQSEIIKRIA LETELNIQTG GGIRSEEQIK DYLDNGVSSV IVGSMAAVEP EKAKGWIKTF 130 140 150 160 170 180 GKERIVLSLD VNIVNNEPFV AAYGWQGSSG KNLFDLINGY TLQGLRVLCT DISRDGALQG 190 200 210 220 230 240 PNIDLYKNVL NKCPGVELQA SGGVAGLNDL IKLKETGVHG VIVGKALYER KFTLREALSI

References

[1]

"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)." Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A. Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pei191.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001055 Genomic DNA. Translation: ACC98272.1.
RefSeq	YP_001875609.1. NC_010644.1.
3D structure databases
ProteinModelPortal	B2KCM6.
ModBase	Search...
Protein-protein interaction databases
STRING	445932.Emin_0717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACC98272; ACC98272; Emin_0717.
GeneID	6263657.
KEGG	emi:Emin_0717.
PATRIC	21848624. VBIEluMin86178_0749.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0106.
HOGENOM	HOG000224614.
KO	K01814.
OMA	KIAVSGW.
Enzyme and pathway databases
BioCyc	EMIN445932:GHM0-742-MONOMER.
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR006063. HisA. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00007. TIGR00007. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_ELUMP

Accession

Primary (citable) accession number: B2KCM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	May 29, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program