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B2KCM3 (B2KCM3_ELUMP) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079

Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079
Ordered Locus Names:Emin_0714 EMBL ACC98269.1
OrganismElusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP] EMBL ACC98269.1
Taxonomic identifier445932 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079 SAAS SAAS013820

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079 SAAS SAAS013820

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
B2KCM3 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 6E5BA5A7A936EFC3

FASTA29531,997
        10         20         30         40         50         60 
MKNKETRLNI ALQKSGRLSE KSFELLSKCG LELAQGKRSL ICRSQELPVD VLLLRDDDVP 

        70         80         90        100        110        120 
TFVSEGVCDI GIVGQNVLLE ETLGTKEGEN LETVMELGFS GCRLSIALPK EKEYNSLEDI 

       130        140        150        160        170        180 
KGCKLATTYP KILQNFLDKN KINAMAVKME GSVEIAPSLG LADGICDIVS SGATLEAHGL 

       190        200        210        220        230        240 
VEVEKIFQSQ AVLVGRKNMS VEKRAILVTI LERIKGVRAA AKSKYVMLNA PKSKLKDICA 

       250        260        270        280        290 
LLPGSESPTI IPLADENKVA VHAVCLEPVF WSTMESLKSA GATSVLILPI EKMLV 

« Hide

References

[1]"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
Herlemann D.P., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pei191 EMBL ACC98269.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001055 Genomic DNA. Translation: ACC98269.1.
RefSeqYP_001875606.1. NC_010644.1.

3D structure databases

ProteinModelPortalB2KCM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445932.Emin_0714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC98269; ACC98269; Emin_0714.
GeneID6263421.
KEGGemi:Emin_0714.
PATRIC21848618. VBIEluMin86178_0746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0040.
HOGENOMHOG000223247.
KOK00765.
OMAVATEFPN.
OrthoDBEOG66MQT3.

Enzyme and pathway databases

BioCycEMIN445932:GHM0-739-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. SSF54913. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2KCM3_ELUMP
AccessionPrimary (citable) accession number: B2KCM3
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)