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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Elusimicrobium minutum (strain Pei191)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (Emin_0712)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotationSAAS annotation (EC:2.4.2.17UniRule annotationSAAS annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:Emin_0714Imported
OrganismiElusimicrobium minutum (strain Pei191)Imported
Taxonomic identifieri445932 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
Proteomesi
  • UP000001029 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi445932.Emin_0714.

Structurei

3D structure databases

ProteinModelPortaliB2KCM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 216HisGInterPro annotationAdd BLAST162
Domaini220 – 292HisG_CInterPro annotationAdd BLAST73

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223247.
KOiK00765.
OMAiYVMMDYD.
OrthoDBiPOG091H05D7.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2KCM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKETRLNI ALQKSGRLSE KSFELLSKCG LELAQGKRSL ICRSQELPVD
60 70 80 90 100
VLLLRDDDVP TFVSEGVCDI GIVGQNVLLE ETLGTKEGEN LETVMELGFS
110 120 130 140 150
GCRLSIALPK EKEYNSLEDI KGCKLATTYP KILQNFLDKN KINAMAVKME
160 170 180 190 200
GSVEIAPSLG LADGICDIVS SGATLEAHGL VEVEKIFQSQ AVLVGRKNMS
210 220 230 240 250
VEKRAILVTI LERIKGVRAA AKSKYVMLNA PKSKLKDICA LLPGSESPTI
260 270 280 290
IPLADENKVA VHAVCLEPVF WSTMESLKSA GATSVLILPI EKMLV
Length:295
Mass (Da):31,997
Last modified:June 10, 2008 - v1
Checksum:i6E5BA5A7A936EFC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001055 Genomic DNA. Translation: ACC98269.1.
RefSeqiWP_012414884.1. NC_010644.1.

Genome annotation databases

EnsemblBacteriaiACC98269; ACC98269; Emin_0714.
KEGGiemi:Emin_0714.
PATRICi21848618. VBIEluMin86178_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001055 Genomic DNA. Translation: ACC98269.1.
RefSeqiWP_012414884.1. NC_010644.1.

3D structure databases

ProteinModelPortaliB2KCM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi445932.Emin_0714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC98269; ACC98269; Emin_0714.
KEGGiemi:Emin_0714.
PATRICi21848618. VBIEluMin86178_0746.

Phylogenomic databases

eggNOGiENOG4105E21. Bacteria.
COG0040. LUCA.
HOGENOMiHOG000223247.
KOiK00765.
OMAiYVMMDYD.
OrthoDBiPOG091H05D7.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long. 1 hit.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2KCM3_ELUMP
AccessioniPrimary (citable) accession number: B2KCM3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.