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B2KCF7 (PUR9_ELUMP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Emin_0523
OrganismElusimicrobium minutum (strain Pei191) [Complete proteome] [HAMAP]
Taxonomic identifier445932 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000096063

Sequences

Sequence LengthMass (Da)Tools
B2KCF7 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: D4EE7C5191FD09D7

FASTA51757,049
        10         20         30         40         50         60 
MTQERKIKRA LISVSDKTGL EVFAKGLHKL GVELVSTSGT AKFLKAAGLP VRDLSDLTGF 

        70         80         90        100        110        120 
PEILDGRVKT LHPRVHGAIL YKRDDDAHCK VIKDMGIEDI DMLVVNLYPF RETAAKAKHS 

       130        140        150        160        170        180 
FDAEVIENID IGGPSMLRSA AKNFAHVAVL CRPKDYEVVL SEMAASQGAL SYATRQRLCV 

       190        200        210        220        230        240 
EAFTHTAEYD AAISEEFKKG LNHEFPESKI VVLHKTQDLR YGENPHQKAV LYSQKKDFSF 

       250        260        270        280        290        300 
EQLHGKELSY NNILDAFGTW DAVCDFDLPA CVIFKHVTPC GIGTGKVLTE AFNNAWACDP 

       310        320        330        340        350        360 
KSAFGGIIAL NKPMQRDIAE AISKVFIEAV CAPDYDLESL EILKQKKNIR ILKRNSPLSA 

       370        380        390        400        410        420 
AYQLKSVGDE VLLQQPDRTL LLDNKWDCVT KRKPTEEEDK ALKFAWASVK HVKSNAVILT 

       430        440        450        460        470        480 
SESASVGIGA GQMSRVDSVK MAGMKFEEYL QENKKPKVLV IGSDAFFPFR DGVDAAAKLG 

       490        500        510 
VSAIVQPGGS VRDEEAIAAA DEHGIAMIFT GLRHFRH 

« Hide

References

[1]"Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pei191.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001055 Genomic DNA. Translation: ACC98078.1.
RefSeqYP_001875415.1. NC_010644.1.

3D structure databases

ProteinModelPortalB2KCF7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445932.Emin_0523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC98078; ACC98078; Emin_0523.
GeneID6262650.
KEGGemi:Emin_0523.
PATRIC21848204. VBIEluMin86178_0541.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycEMIN445932:GHM0-546-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_ELUMP
AccessionPrimary (citable) accession number: B2KCF7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways