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B2KB05

- SYL_ELUMP

UniProt

B2KB05 - SYL_ELUMP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Elusimicrobium minutum (strain Pei191)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei614 – 6141ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEMIN445932:GHM0-208-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Emin_0201
    OrganismiElusimicrobium minutum (strain Pei191)
    Taxonomic identifieri445932 [NCBI]
    Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
    ProteomesiUP000001029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_1000091316Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi445932.Emin_0201.

    Structurei

    3D structure databases

    ProteinModelPortaliB2KB05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5212"HIGH" regionAdd
    BLAST
    Motifi611 – 6155"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2KB05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEINFQEID KKQQKIWEDN NLFVTPRLPI NPKFYCLDMF PYPSGQGLHV    50
    GHPEGYTASD ILVRYKKMKG FDVIHPMGWD AFGLPAENYA IATGVHPAIT 100
    TKNNIDNFRR QIKSLGMAYD WTREIDTTDP NYYRWTQWIF LQIFKKGLAY 150
    ESTVPINWCP SCKTGLANEE VFNGNCERCG TKIESKNIRQ WVLKITEYAD 200
    RLLEDLEGLD WPESTLAMQR NWIGKSIGAE VDFEIDGHKE NLKVFTTRPD 250
    TLFGATYMVV SPEHPILEQI TMPEQKAAVK SYQEEAAAKT DFERGDVNKK 300
    TGVFTGAYAI NPVNGKKIQI WTSDYVLMGY GTGAIMAVPA HDERDYEFAK 350
    KFGLEIIEVI KSDKGVEKEA FTGDGELVNS DFLNGMKVEQ SKAAMIKFLE 400
    EKGVGGAKTT YRLRDWVFSR QRYWGEPIPI VHCPKCGVVP VPESELPVKL 450
    PEVTNYEPTG TGESPLANVP EWVNTVCPVC AGPAKRETNT MPQWAGSCWY 500
    YLRYLDPKND KTFVNPEIER ECDPVDCYIG GAEHAVLHLL YSRFWHKVLY 550
    DLGYVKYKEP YAKLRHQGMI LAYSYRGEDG VYHGYDEVDL SDLQNPKLKT 600
    TGEKLNSMVE KMSKSKKNVI NPDDILHKYG ADAFRMYEMF MGPFEASKPW 650
    DMKGIEGVNR FLKRVYAWGE SVETDEVFLS TKELDILRSK TIVKVSEDIE 700
    KFNFNTAVSA LMIYFNDLSK IKGVPLKHFK TFLALLHPFA PHITEELWSR 750
    RKCGPFLVKT AWPEADIMLL RSEDMGLGIQ VNGKVRGSIT VNASASDDEI 800
    KAKAFEEPNV KKHMEGKALV KVIIVPKRMV NIVVK 835
    Length:835
    Mass (Da):95,166
    Last modified:June 10, 2008 - v1
    Checksum:i955DAACAC38CCF7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC97764.1.
    RefSeqiWP_012414379.1. NC_010644.1.
    YP_001875101.1. NC_010644.1.

    Genome annotation databases

    EnsemblBacteriaiACC97764; ACC97764; Emin_0201.
    GeneIDi6262872.
    KEGGiemi:Emin_0201.
    PATRICi21847506. VBIEluMin86178_0207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001055 Genomic DNA. Translation: ACC97764.1 .
    RefSeqi WP_012414379.1. NC_010644.1.
    YP_001875101.1. NC_010644.1.

    3D structure databases

    ProteinModelPortali B2KB05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 445932.Emin_0201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC97764 ; ACC97764 ; Emin_0201 .
    GeneIDi 6262872.
    KEGGi emi:Emin_0201.
    PATRICi 21847506. VBIEluMin86178_0207.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci EMIN445932:GHM0-208-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of 'Elusimicrobium minutum,' the first cultivated representative of the phylum 'Elusimicrobia' (formerly termite group 1)."
      Herlemann D.P.R., Geissinger O., Ikeda-Ohtsubo W., Kunin V., Sun H., Lapidus A., Hugenholtz P., Brune A.
      Appl. Environ. Microbiol. 75:2841-2849(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pei191.

    Entry informationi

    Entry nameiSYL_ELUMP
    AccessioniPrimary (citable) accession number: B2KB05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3