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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98ZincUniRule annotation1
Metal bindingi100ZincUniRule annotation1
Metal bindingi125ZincUniRule annotation1
Metal bindingi127ZincUniRule annotation1
Binding sitei240ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:YPTS_2806
OrganismiYersinia pseudotuberculosis serotype IB (strain PB1/+)
Taxonomic identifieri502801 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000901261 – 471Glutamate--tRNA ligaseAdd BLAST471

Proteomic databases

PRIDEiB2K913

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2K913
SMRiB2K913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi237 – 241"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2K913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTRFAPS PTGYLHVGGA RTALYSWLFS RHLGGEFVLR IEDTDLERST
60 70 80 90 100
QEAIDAIMDG MNWLNLDWDE GPYFQTKRFD RYNAVIDQML DAGTAYRCYC
110 120 130 140 150
SKERLEALRE AQMANGEKPR YDGHCRDSQC THGADEPSVV RFRNPQEGSV
160 170 180 190 200
IFDDKIRGPI EFSNQELDDL IIRRTDGSPT YNFCVVIDDW DMEITHVIRG
210 220 230 240 250
EDHINNTPRQ INILKALGAP VPEYAHVSMI LGDDGKKLSK RHGAVGVMQY
260 270 280 290 300
RDDGYLPEAL LNYLVRLGWS HGDQEIFSIE EMTQLFTLDA VSKSASAFNT
310 320 330 340 350
EKLQWLNHHY INSLPPEQVA VHLSWHVEQL GIDTRNGPEL VEIVKLLGER
360 370 380 390 400
CKTLKEMAES CRYFYEEFDA FDVDAAKKHL RPIARQPLEA VKVKLAAITE
410 420 430 440 450
WTTENVHNAI QGTADELGVG MGKVGMPLRV AVTGVGQSPG MDVTVHAIGQ
460 470
ARTLARIDKA LAFISEREAQ Q
Length:471
Mass (Da):53,182
Last modified:June 10, 2008 - v1
Checksum:i92591583BDB9582C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001048 Genomic DNA Translation: ACC89764.1
RefSeqiWP_011192732.1, NZ_CP009780.1

Genome annotation databases

EnsemblBacteriaiACC89764; ACC89764; YPTS_2806
KEGGiypb:YPTS_2806
PATRICifig|502801.10.peg.2233

Similar proteinsi

Entry informationi

Entry nameiSYE_YERPB
AccessioniPrimary (citable) accession number: B2K913
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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