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B2K8U4 (BETA_YERPB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:YPTS_1275
OrganismYersinia pseudotuberculosis serotype IB (strain PB1/+) [Complete proteome] [HAMAP]
Taxonomic identifier502801 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000133341

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4731 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2K8U4 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 190523566F03FF5D

FASTA56762,450
        10         20         30         40         50         60 
MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA LAFPLQGKRY 

        70         80         90        100        110        120 
NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDHWASL SGLEDWSYLD 

       130        140        150        160        170        180 
CLPYFRKAET RDVGPNDFHG GEGPVSVTTP KIDNNPLFHA MVAAGVQAGY PRTDDLNGYQ 

       190        200        210        220        230        240 
QEGFGPMDRT VTPKGRRAST ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVSYLKG 

       250        260        270        280        290        300 
DAGTGQTAHA RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL 

       310        320        330        340        350        360 
EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR SRDAFTWPNI 

       370        380        390        400        410        420 
QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK SKDPRQHPSI LFNYMSNEQD 

       430        440        450        460        470        480 
WHEFRDAIRI TREIIAQPAL DPYRGREISP GANVQSDDEL DAFIREHAET AYHPSCSCKM 

       490        500        510        520        530        540 
GDDKMAVVDG QGRVHGVQGL RVVDASIMPQ IITGNLNATT IMIAEKIADR IRGCQPLAKS 

       550        560 
NAAYFIAGDT PARTSPVRHS LPVTSYP 

« Hide

References

[1]"Complete sequence of Yersinia pseudotuberculosis PB1/+."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PB1/+.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001048 Genomic DNA. Translation: ACC88250.1.
RefSeqYP_001871707.1. NC_010634.1.

3D structure databases

ProteinModelPortalB2K8U4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING502801.YPTS_1275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC88250; ACC88250; YPTS_1275.
GeneID6258626.
KEGGypb:YPTS_1275.
PATRIC18650302. VBIYerPse20639_1369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycYPSE502801:GHIH-1393-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_YERPB
AccessionPrimary (citable) accession number: B2K8U4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways