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B2K8U4

- BETA_YERPB

UniProt

B2K8U4 - BETA_YERPB

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei473 – 4731UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciYPSE502801:GHIH-1393-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:YPTS_1275
    OrganismiYersinia pseudotuberculosis serotype IB (strain PB1/+)
    Taxonomic identifieri502801 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001193: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_1000133341Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi502801.YPTS_1275.

    Structurei

    3D structure databases

    ProteinModelPortaliB2K8U4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2K8U4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA    50
    LAFPLQGKRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN 100
    AMDFDHWASL SGLEDWSYLD CLPYFRKAET RDVGPNDFHG GEGPVSVTTP 150
    KIDNNPLFHA MVAAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPKGRRAST 200
    ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVSYLKG DAGTGQTAHA 250
    RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL 300
    EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR 350
    SRDAFTWPNI QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK 400
    SKDPRQHPSI LFNYMSNEQD WHEFRDAIRI TREIIAQPAL DPYRGREISP 450
    GANVQSDDEL DAFIREHAET AYHPSCSCKM GDDKMAVVDG QGRVHGVQGL 500
    RVVDASIMPQ IITGNLNATT IMIAEKIADR IRGCQPLAKS NAAYFIAGDT 550
    PARTSPVRHS LPVTSYP 567
    Length:567
    Mass (Da):62,450
    Last modified:June 10, 2008 - v1
    Checksum:i190523566F03FF5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001048 Genomic DNA. Translation: ACC88250.1.
    RefSeqiYP_001871707.1. NC_010634.1.

    Genome annotation databases

    EnsemblBacteriaiACC88250; ACC88250; YPTS_1275.
    GeneIDi6258626.
    KEGGiypb:YPTS_1275.
    PATRICi18650302. VBIYerPse20639_1369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001048 Genomic DNA. Translation: ACC88250.1 .
    RefSeqi YP_001871707.1. NC_010634.1.

    3D structure databases

    ProteinModelPortali B2K8U4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 502801.YPTS_1275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC88250 ; ACC88250 ; YPTS_1275 .
    GeneIDi 6258626.
    KEGGi ypb:YPTS_1275.
    PATRICi 18650302. VBIYerPse20639_1369.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci YPSE502801:GHIH-1393-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Yersinia pseudotuberculosis PB1/+."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.
      , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PB1/+.

    Entry informationi

    Entry nameiBETA_YERPB
    AccessioniPrimary (citable) accession number: B2K8U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3