apaH

Functionⁱ

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityⁱ

P₁,P₄-bis(5'-adenosyl) tetraphosphate + H₂O = 2 ADP.UniRule annotation

GO - Molecular functionⁱ

bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation) Alternative name(s): Ap4A hydrolaseUniRule annotation Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation Diadenosine tetraphosphataseUniRule annotation
Gene namesⁱ	Name:apaHUniRule annotation Ordered Locus Names:YPTS_0654
Organismⁱ	Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Taxonomic identifierⁱ	502801 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia › Yersinia pseudotuberculosis

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000099342	1 – 289	Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST		289

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B2K485.
SMRⁱ	B2K485.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000251871.
KEGG Orthology (KO) More...KOⁱ	K01525.
OMAⁱ	MPWFDVP.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07422. MPP_ApaH. 1 hit.
Gene3Dⁱ	3.60.21.10. 1 hit.
HAMAPⁱ	MF_00199. ApaH. 1 hit.
InterProⁱ	View protein in InterPro IPR004617. ApaH. IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit.
PIRSFⁱ	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsⁱ	TIGR00668. apaH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B2K485-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSTYLIGDIH GCLDELLALL AQVNFDPQQD TLWLTGDLVA RGPASLDVLR 
        60         70         80         90        100
YVRSLGPAVR MVLGNHDLHL LAVYAGISRN KPKDRITPLL DAPDADELIN 
       110        120        130        140        150
WLRRQPVLQV DDQLKLIMAH AGITPQWDIE TAKMCAREVE AVLSSDSYPL 
       160        170        180        190        200
FLDAMYGDMP NNWSPELTGL ARLRFSTNAL TRMRFCFPNG QLDMICKDTP 
       210        220        230        240        250
ENAPAPLKPW FDLPRLVDPE YSIIFGHWAS LEGKGVPEGI YGLDTGCCWG 
       260        270        280 
GDLTLLRWED KRYFTQRAFK AEAEINNNNG FAAGEEVQH

Length:289

Mass (Da):32,413

Last modified:June 10, 2008 - v1

Checksum:ⁱ74C61EBA4A6A4B5A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001048 Genomic DNA. Translation: ACC87638.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011191708.1. NZ_CP009780.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACC87638; ACC87638; YPTS_0654.
KEGGⁱ	ypb:YPTS_0654.
PATRICⁱ	fig\|502801.10.peg.4339.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B2K485	Q66ER0 A0A2A7VNB3 A0A0U1ENV5	Yersinia pseudotuberculosis serotype I (strain IP32953) Yersinia pseudotuberculosis Yersinia intermedia	289	UniRef100_B2K485	Cluster: Bis(5'-nucleosyl)-tetraphosphatase, symmetrical	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B2K485	A1JJF2 A0A2G4TQN6 A0A0T9TA64 A0A0E1NFR5 F4N508 A0A0H3P0M5 A0A0T9U2R0 A0A0T9SZL3 A0A0T9LD86 A0A2A7T799 +69	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) Yersinia massiliensis Yersinia frederiksenii Yersinia enterocolitica Yersinia enterocolitica W22703 Yersinia enterocolitica subsp. palearctica serotype O:3 (strain DSM 13030 / CIP 106945 / Y11) Yersinia aldovae Yersinia kristensenii Yersinia enterocolitica LC20 Yersinia bercovieri And more	292	UniRef90_A1JJF2	Cluster: Bis(5'-nucleosyl)-tetraphosphatase, symmetrical	80

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B2K485	C5B7N9 A0A076LQF2 A0A034T298 UPI0009BF7A91 A0A0H3DMW3 A0A1D7V5S7 D0ZC44 A0A1D8RX59 A0A090AK03 A0A1K3H5L2 +580	Edwardsiella ictaluri (strain 93-146) Edwardsiella anguillarum ET080813 Edwardsiella piscicida Edwardsiella ictaluri Edwardsiella tarda (strain FL6-60) Edwardsiella tarda (strain EIB202) Colwellia sp. PAMC 20917 Candidatus Tachikawaea gelatinosa Mycobacterium tuberculosis Morganella morganii (Proteus morganii) And more	279	UniRef50_C5B7N9	Cluster: Bis(5'-nucleosyl)-tetraphosphatase, symmetrical	591

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001048 Genomic DNA. Translation: ACC87638.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011191708.1. NZ_CP009780.1.

3D structure databases

ProteinModelPortalⁱ	B2K485.
SMRⁱ	B2K485.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACC87638; ACC87638; YPTS_0654.
KEGGⁱ	ypb:YPTS_0654.
PATRICⁱ	fig\|502801.10.peg.4339.

Phylogenomic databases

HOGENOMⁱ	HOG000251871.
KEGG Orthology (KO) More...KOⁱ	K01525.
OMAⁱ	MPWFDVP.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07422. MPP_ApaH. 1 hit.
Gene3Dⁱ	3.60.21.10. 1 hit.
HAMAPⁱ	MF_00199. ApaH. 1 hit.
InterProⁱ	View protein in InterPro IPR004617. ApaH. IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit.
PIRSFⁱ	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsⁱ	TIGR00668. apaH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	APAH_YERPB
Accessionⁱ	B2K485Primary (citable) accession number: B2K485
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
	Last sequence update:	June 10, 2008
	Last modified:	March 28, 2018
	This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - B2K485 (APAH_YERPB)

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Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2K485 (APAH_YERPB)

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Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

apaH

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Molecule processing

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3D structure databases

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Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protocols and materials databases

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Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ