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B2K3T5

- B2K3T5_YERPB

UniProt

B2K3T5 - B2K3T5_YERPB

Protein

Thymidine kinase

Gene

tdk

Organism
Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi182 – 1821ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi87 – 904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciYPSE502801:GHIH-2294-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:YPTS_2170Imported
    OrganismiYersinia pseudotuberculosis serotype IB (strain PB1/+)Imported
    Taxonomic identifieri502801 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001193: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiB2K3T5.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi502801.YPTS_2170.

    Structurei

    3D structure databases

    ProteinModelPortaliB2K3T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiELKTVCH.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2K3T5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTLVFTAEI DNRFGVGTVS    50
    SRIGLSSQAQ LYNSGTSLLS IIAAEHQDTP IHCILLDECQ FLTKEQVQEL 100
    CQVVDELHLP VLCYGLRTDF LGELFPGSKY LLAWADKLVE LKTICHCGRK 150
    ANMVLRLDEQ GRAVHNGEQV VIGGNESYVS VCRRHYKEAI KAACCS 196
    Length:196
    Mass (Da):21,897
    Last modified:June 10, 2008 - v1
    Checksum:iF3333069CBFA5958
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001048 Genomic DNA. Translation: ACC89131.1.
    RefSeqiYP_001872588.1. NC_010634.1.

    Genome annotation databases

    EnsemblBacteriaiACC89131; ACC89131; YPTS_2170.
    GeneIDi6259527.
    KEGGiypb:YPTS_2170.
    PATRICi18652276. VBIYerPse20639_2342.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001048 Genomic DNA. Translation: ACC89131.1 .
    RefSeqi YP_001872588.1. NC_010634.1.

    3D structure databases

    ProteinModelPortali B2K3T5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 502801.YPTS_2170.

    Proteomic databases

    PRIDEi B2K3T5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC89131 ; ACC89131 ; YPTS_2170 .
    GeneIDi 6259527.
    KEGGi ypb:YPTS_2170.
    PATRICi 18652276. VBIYerPse20639_2342.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi ELKTVCH.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci YPSE502801:GHIH-2294-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Yersinia pseudotuberculosis PB1/+."
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.
      , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PB1/+Imported.

    Entry informationi

    Entry nameiB2K3T5_YERPB
    AccessioniPrimary (citable) accession number: B2K3T5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3