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B2JS89

- BETA_BURP8

UniProt

B2JS89 - BETA_BURP8

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, Bphy_3310
Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei474 – 4741 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-3379-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Bphy_3310
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_1000133324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_3310.

Structurei

3D structure databases

ProteinModelPortaliB2JS89.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiLTDDYNG.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2JS89-1 [UniParc]FASTAAdd to Basket

« Hide

MAAKEYDYII IGAGSAGNVL ATRLTEDRDV TVLLLEAGGP DYRFDFRTQM    50
PAALAYPLQG RRYNWAYETD PEPFMNNRRM ECGRGKGLGG SSLINGMCYI 100
RGNALDYDGW AERKGLENWT YLDCLPYFRK AETRDAGAND YHGGDGPVHV 150
TTSKRGVNPL FEAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTANGRR 200
ASTARGYLDQ ARPRPNLTIV TYATTDRILF SGKRAQGVVY LDGQAQITAH 250
ARREVLLCSG AIASPQILQR SGVGPGGWLR DLDIPVVLDL PGVGQNLQDH 300
LEMYMQYECK EPVSLYPALL LRNQPAIGIE WMLKGTGIGA SNHFEAGGFI 350
RTRDDDPWPN IQYHFLPVAI NYNGTNAIKM HGFQAHVGSM RSPSRGRVKL 400
RSRDPREHPS ILFNYMAEAL DWREFRDAIR ITREIIAQPA LDRFRGRELS 450
PGAELQSDAQ IDAFVRARAE TAYHPSCSCA MGYDDMAVVD GEGRVHGLEG 500
LRVVDASIMP RITTGNLNAP TIMLAEKIAD RIRGRAPLAR STAPYYVANG 550
APARGAKHVE HAPAPSVAAH TH 572
Length:572
Mass (Da):63,110
Last modified:June 10, 2008 - v1
Checksum:i8484418C99549861
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC72466.1.
RefSeqiYP_001859512.1. NC_010623.1.

Genome annotation databases

EnsemblBacteriaiACC72466; ACC72466; Bphy_3310.
GeneIDi6244741.
KEGGibph:Bphy_3310.
PATRICi19193205. VBIBurPhy25146_3495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC72466.1 .
RefSeqi YP_001859512.1. NC_010623.1.

3D structure databases

ProteinModelPortali B2JS89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_3310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC72466 ; ACC72466 ; Bphy_3310 .
GeneIDi 6244741.
KEGGi bph:Bphy_3310.
PATRICi 19193205. VBIBurPhy25146_3495.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi LTDDYNG.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci BPHY391038:GI4Z-3379-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiBETA_BURP8
AccessioniPrimary (citable) accession number: B2JS89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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