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B2JS88

- BETB_BURP8

UniProt

B2JS88 - BETB_BURP8

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, Bphy_3309
Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Potassium 1 By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi245 – 2451Potassium 2; via carbonyl oxygen By similarity
Sitei247 – 2471Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei251 – 2511Proton acceptor By similarity
Binding sitei285 – 2851NAD/NADP By similarity
Binding sitei386 – 3861NAD/NADP By similarity
Metal bindingi456 – 4561Potassium 2; via carbonyl oxygen By similarity
Metal bindingi459 – 4591Potassium 2; via carbonyl oxygen By similarity
Active sitei463 – 4631Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi228 – 2336NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-3378-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:Bphy_3309
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000133944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391038.Bphy_3309.

Structurei

3D structure databases

ProteinModelPortaliB2JS88.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiSIFEARW.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2JS88-1 [UniParc]FASTAAdd to Basket

« Hide

MSAYGLQRLY IGGDYVDATS GVTFDTFDPA TGELLATVQQ ASEADIERAV    50
QSAREGQRAW AAMTAMQRSR ILRRAVDLLR ERNDELAELE MRDTGKPIAE 100
TRAVDIVTGA DVIEYYAGLA TAIEGQQIPL RAESFVYTRR EPLGVTAGIG 150
AWNYPIQIAC WKSAPALAAG NAMIFKPSEV TPLSASKLAE IYLEAGVPAG 200
VFNVVQGDGR VGAMLSAHPG IAKISFTGGV ETGKKVMSMA GGSSLKEVTM 250
ELGGKSPLVV FEDADLDRAA DIAVTANFFS AGQVCTNGTR VFVHQSVQPA 300
FEARVIERVK RIRVGKPSDP STNFGPLASA AQLDKVLGFI ESGKREGARL 350
VAGGARIVEG DYARGQYVQP TVFSDCRDDM KIVREEIFGP VMSILSFVDE 400
DDVIERANDT IYGLAAGVVT ENLARAHRAI HRLEAGICWI NTWGESPAEM 450
PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGKYQPVF 489
Length:489
Mass (Da):52,647
Last modified:June 10, 2008 - v1
Checksum:iD0EC8BB1F4E493A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC72465.1.
RefSeqiWP_012402638.1. NC_010623.1.
YP_001859511.1. NC_010623.1.

Genome annotation databases

EnsemblBacteriaiACC72465; ACC72465; Bphy_3309.
GeneIDi6244740.
KEGGibph:Bphy_3309.
PATRICi19193203. VBIBurPhy25146_3494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC72465.1 .
RefSeqi WP_012402638.1. NC_010623.1.
YP_001859511.1. NC_010623.1.

3D structure databases

ProteinModelPortali B2JS88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_3309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC72465 ; ACC72465 ; Bphy_3309 .
GeneIDi 6244740.
KEGGi bph:Bphy_3309.
PATRICi 19193203. VBIBurPhy25146_3494.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi SIFEARW.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci BPHY391038:GI4Z-3378-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiBETB_BURP8
AccessioniPrimary (citable) accession number: B2JS88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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