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B2JS88

- BETB_BURP8

UniProt

B2JS88 - BETB_BURP8

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi26 – 261Potassium 1UniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei162 – 1621Charge relay systemUniRule annotation
    Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi245 – 2451Potassium 2; via carbonyl oxygenUniRule annotation
    Sitei247 – 2471Seems to be a necessary countercharge to the potassium cationsUniRule annotation
    Active sitei251 – 2511Proton acceptorUniRule annotation
    Binding sitei285 – 2851NAD/NADPUniRule annotation
    Binding sitei386 – 3861NAD/NADPUniRule annotation
    Metal bindingi456 – 4561Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi459 – 4591Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei463 – 4631Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
    Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
    Nucleotide bindingi228 – 2336NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciBPHY391038:GI4Z-3378-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:Bphy_3309
    OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
    Taxonomic identifieri391038 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001192: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000133944Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei285 – 2851Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi391038.Bphy_3309.

    Structurei

    3D structure databases

    ProteinModelPortaliB2JS88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiSIFEARW.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2JS88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAYGLQRLY IGGDYVDATS GVTFDTFDPA TGELLATVQQ ASEADIERAV    50
    QSAREGQRAW AAMTAMQRSR ILRRAVDLLR ERNDELAELE MRDTGKPIAE 100
    TRAVDIVTGA DVIEYYAGLA TAIEGQQIPL RAESFVYTRR EPLGVTAGIG 150
    AWNYPIQIAC WKSAPALAAG NAMIFKPSEV TPLSASKLAE IYLEAGVPAG 200
    VFNVVQGDGR VGAMLSAHPG IAKISFTGGV ETGKKVMSMA GGSSLKEVTM 250
    ELGGKSPLVV FEDADLDRAA DIAVTANFFS AGQVCTNGTR VFVHQSVQPA 300
    FEARVIERVK RIRVGKPSDP STNFGPLASA AQLDKVLGFI ESGKREGARL 350
    VAGGARIVEG DYARGQYVQP TVFSDCRDDM KIVREEIFGP VMSILSFVDE 400
    DDVIERANDT IYGLAAGVVT ENLARAHRAI HRLEAGICWI NTWGESPAEM 450
    PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGKYQPVF 489
    Length:489
    Mass (Da):52,647
    Last modified:June 10, 2008 - v1
    Checksum:iD0EC8BB1F4E493A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC72465.1.
    RefSeqiWP_012402638.1. NC_010623.1.
    YP_001859511.1. NC_010623.1.

    Genome annotation databases

    EnsemblBacteriaiACC72465; ACC72465; Bphy_3309.
    GeneIDi6244740.
    KEGGibph:Bphy_3309.
    PATRICi19193203. VBIBurPhy25146_3494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC72465.1 .
    RefSeqi WP_012402638.1. NC_010623.1.
    YP_001859511.1. NC_010623.1.

    3D structure databases

    ProteinModelPortali B2JS88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391038.Bphy_3309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC72465 ; ACC72465 ; Bphy_3309 .
    GeneIDi 6244740.
    KEGGi bph:Bphy_3309.
    PATRICi 19193203. VBIBurPhy25146_3494.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi SIFEARW.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci BPHY391038:GI4Z-3378-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17167 / STM815.

    Entry informationi

    Entry nameiBETB_BURP8
    AccessioniPrimary (citable) accession number: B2JS88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3