Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2JQW0

- HOA2_BURP8

UniProt

B2JQW0 - HOA2_BURP8

Protein

4-hydroxy-2-oxovalerate aldolase 2

Gene

Bphy_4539

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei13 – 131Transition state stabilizerUniRule annotation
    Metal bindingi14 – 141ManganeseUniRule annotation
    Active sitei17 – 171Proton acceptorUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Metal bindingi196 – 1961Manganese; via tele nitrogenUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation
    Metal bindingi198 – 1981Manganese; via tele nitrogenUniRule annotation
    Binding sitei287 – 2871SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-2-oxovalerate aldolase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBPHY391038:GI4Z-4613-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-2-oxovalerate aldolase 2UniRule annotation (EC:4.1.3.39UniRule annotation)
    Short name:
    HOA 2UniRule annotation
    Alternative name(s):
    4-hydroxy-2-keto-pentanoic acid aldolase 2UniRule annotation
    4-hydroxy-2-oxopentanoate aldolase 2UniRule annotation
    Gene namesi
    Ordered Locus Names:Bphy_4539
    OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
    Taxonomic identifieri391038 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001192: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3393394-hydroxy-2-oxovalerate aldolase 2PRO_0000387797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391038.Bphy_4539.

    Structurei

    3D structure databases

    ProteinModelPortaliB2JQW0.
    SMRiB2JQW0. Positions 3-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni13 – 142Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the 4-hydroxy-2-oxovalerate aldolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    HOGENOMiHOG000048047.
    KOiK01666.
    OMAiVGTHCTE.
    OrthoDBiEOG6C2WC0.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01656. HOA.
    InterProiIPR017629. 4OH_2_O-val_aldolase.
    IPR013785. Aldolase_TIM.
    IPR012425. DmpG_comm.
    IPR000891. PYR_CT.
    [Graphical view]
    PANTHERiPTHR10277:SF3. PTHR10277:SF3. 1 hit.
    PfamiPF07836. DmpG_comm. 1 hit.
    PF00682. HMGL-like. 1 hit.
    [Graphical view]
    ProDomiPD005364. DmpG_comm. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR03217. 4OH_2_O_val_ald. 1 hit.
    PROSITEiPS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2JQW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKKLYISDV TLRDGMHAIR HQYSIQNVQD IARALDEAKV DSIEVAHGDG    50
    LQGSSFNYGF GAHSDLEWIE AVADVVRHAK IATLLLPGIG TIHDLKAAYD 100
    AGARVVRVAT HCTEADISKQ HIEYARSLGM DTVGFLMMSH MTTPENLAVE 150
    AKKMESYGAT CVYVVDSGGA MNMNDIRARF MALKATLDPA TQTGMHAHHN 200
    LSLGVANSIV AVEEGCDRVD ASLAGMGAGA GNAPLEVFIA AVERMGWHHG 250
    TDLYRLLDAA DDIVRPLQDR PVRVDRETLA LGYAGVYSSF LRHSEIAANK 300
    YGLKAVDILV ELGKRRMVGG QEDMIVDVAL DLKKREAHA 339
    Length:339
    Mass (Da):36,794
    Last modified:June 10, 2008 - v1
    Checksum:i3897287A46C86A9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC73651.1.
    RefSeqiYP_001860697.1. NC_010623.1.

    Genome annotation databases

    EnsemblBacteriaiACC73651; ACC73651; Bphy_4539.
    GeneIDi6246058.
    KEGGibph:Bphy_4539.
    PATRICi19195821. VBIBurPhy25146_4797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC73651.1 .
    RefSeqi YP_001860697.1. NC_010623.1.

    3D structure databases

    ProteinModelPortali B2JQW0.
    SMRi B2JQW0. Positions 3-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391038.Bphy_4539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC73651 ; ACC73651 ; Bphy_4539 .
    GeneIDi 6246058.
    KEGGi bph:Bphy_4539.
    PATRICi 19195821. VBIBurPhy25146_4797.

    Phylogenomic databases

    eggNOGi COG0119.
    HOGENOMi HOG000048047.
    KOi K01666.
    OMAi VGTHCTE.
    OrthoDBi EOG6C2WC0.

    Enzyme and pathway databases

    BioCyci BPHY391038:GI4Z-4613-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01656. HOA.
    InterProi IPR017629. 4OH_2_O-val_aldolase.
    IPR013785. Aldolase_TIM.
    IPR012425. DmpG_comm.
    IPR000891. PYR_CT.
    [Graphical view ]
    PANTHERi PTHR10277:SF3. PTHR10277:SF3. 1 hit.
    Pfami PF07836. DmpG_comm. 1 hit.
    PF00682. HMGL-like. 1 hit.
    [Graphical view ]
    ProDomi PD005364. DmpG_comm. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR03217. 4OH_2_O_val_ald. 1 hit.
    PROSITEi PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17167 / STM815.

    Entry informationi

    Entry nameiHOA2_BURP8
    AccessioniPrimary (citable) accession number: B2JQW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3