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B2JQV9

- ACDH2_BURP8

UniProt

B2JQV9 - ACDH2_BURP8

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Protein
Acetaldehyde dehydrogenase 2
Gene
Bphy_4538
Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Acyl-thioester intermediate By similarity
Binding sitei293 – 2931NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi166 – 1749NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-4612-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:Bphy_4538
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Acetaldehyde dehydrogenase 2UniRule annotation
PRO_1000187028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_4538.

Structurei

3D structure databases

ProteinModelPortaliB2JQV9.
SMRiB2JQV9. Positions 5-315.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B2JQV9-1 [UniParc]FASTAAdd to Basket

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MATDNTKRKA AIIGSGNIGT DLMIKIMRRS RHLDVAAMVG IDPASDGLAR    50
AAKLGVATTH EGVQGLTRLS VFDEIDFVFD ATSAGAHVKN DAFLRTLKPG 100
IRVIDLTPAA IGPYCVPVVN LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV 150
AKVHYAEIVA SISSRSAGPG TRANIDEFTE TTSKAIEAVG GAGKGKAIIV 200
LNPAEPPLMM RDTVYVLSEA ADRAQIEASV ERMAAAVQAY VPGYRLKQSV 250
QFDDIPANAP LHIPGLGRFS GLKTSVFIEV EGAAHYLPAY AGNLDIMTSA 300
ALATAERMAA SLVNA 315
Length:315
Mass (Da):32,933
Last modified:June 10, 2008 - v1
Checksum:iFA0E11697D678AA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC73650.1.
RefSeqiWP_012403822.1. NC_010623.1.
YP_001860696.1. NC_010623.1.

Genome annotation databases

EnsemblBacteriaiACC73650; ACC73650; Bphy_4538.
GeneIDi6246057.
KEGGibph:Bphy_4538.
PATRICi19195819. VBIBurPhy25146_4796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC73650.1 .
RefSeqi WP_012403822.1. NC_010623.1.
YP_001860696.1. NC_010623.1.

3D structure databases

ProteinModelPortali B2JQV9.
SMRi B2JQV9. Positions 5-315.
ModBasei Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_4538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC73650 ; ACC73650 ; Bphy_4538 .
GeneIDi 6246057.
KEGGi bph:Bphy_4538.
PATRICi 19195819. VBIBurPhy25146_4796.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BPHY391038:GI4Z-4612-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiACDH2_BURP8
AccessioniPrimary (citable) accession number: B2JQV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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