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B2JQV9

- ACDH2_BURP8

UniProt

B2JQV9 - ACDH2_BURP8

Protein

Acetaldehyde dehydrogenase 2

Gene

Bphy_4538

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351Acyl-thioester intermediateUniRule annotation
    Binding sitei293 – 2931NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi166 – 1749NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBPHY391038:GI4Z-4612-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:Bphy_4538
    OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
    Taxonomic identifieri391038 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001192: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Acetaldehyde dehydrogenase 2PRO_1000187028Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391038.Bphy_4538.

    Structurei

    3D structure databases

    ProteinModelPortaliB2JQV9.
    SMRiB2JQV9. Positions 5-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2JQV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATDNTKRKA AIIGSGNIGT DLMIKIMRRS RHLDVAAMVG IDPASDGLAR    50
    AAKLGVATTH EGVQGLTRLS VFDEIDFVFD ATSAGAHVKN DAFLRTLKPG 100
    IRVIDLTPAA IGPYCVPVVN LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV 150
    AKVHYAEIVA SISSRSAGPG TRANIDEFTE TTSKAIEAVG GAGKGKAIIV 200
    LNPAEPPLMM RDTVYVLSEA ADRAQIEASV ERMAAAVQAY VPGYRLKQSV 250
    QFDDIPANAP LHIPGLGRFS GLKTSVFIEV EGAAHYLPAY AGNLDIMTSA 300
    ALATAERMAA SLVNA 315
    Length:315
    Mass (Da):32,933
    Last modified:June 10, 2008 - v1
    Checksum:iFA0E11697D678AA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC73650.1.
    RefSeqiWP_012403822.1. NC_010623.1.
    YP_001860696.1. NC_010623.1.

    Genome annotation databases

    EnsemblBacteriaiACC73650; ACC73650; Bphy_4538.
    GeneIDi6246057.
    KEGGibph:Bphy_4538.
    PATRICi19195819. VBIBurPhy25146_4796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC73650.1 .
    RefSeqi WP_012403822.1. NC_010623.1.
    YP_001860696.1. NC_010623.1.

    3D structure databases

    ProteinModelPortali B2JQV9.
    SMRi B2JQV9. Positions 5-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391038.Bphy_4538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC73650 ; ACC73650 ; Bphy_4538 .
    GeneIDi 6246057.
    KEGGi bph:Bphy_4538.
    PATRICi 19195819. VBIBurPhy25146_4796.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BPHY391038:GI4Z-4612-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17167 / STM815.

    Entry informationi

    Entry nameiACDH2_BURP8
    AccessioniPrimary (citable) accession number: B2JQV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3