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B2JQV9 (ACDH2_BURP8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Ordered Locus Names:Bphy_4538
OrganismBurkholderia phymatum (strain DSM 17167 / STM815) [Complete proteome] [HAMAP]
Taxonomic identifier391038 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_1000187028

Regions

Nucleotide binding15 – 184NAD By similarity
Nucleotide binding166 – 1749NAD By similarity

Sites

Active site1351Acyl-thioester intermediate By similarity
Binding site2931NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B2JQV9 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: FA0E11697D678AA0

FASTA31532,933
        10         20         30         40         50         60 
MATDNTKRKA AIIGSGNIGT DLMIKIMRRS RHLDVAAMVG IDPASDGLAR AAKLGVATTH 

        70         80         90        100        110        120 
EGVQGLTRLS VFDEIDFVFD ATSAGAHVKN DAFLRTLKPG IRVIDLTPAA IGPYCVPVVN 

       130        140        150        160        170        180 
LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV AKVHYAEIVA SISSRSAGPG TRANIDEFTE 

       190        200        210        220        230        240 
TTSKAIEAVG GAGKGKAIIV LNPAEPPLMM RDTVYVLSEA ADRAQIEASV ERMAAAVQAY 

       250        260        270        280        290        300 
VPGYRLKQSV QFDDIPANAP LHIPGLGRFS GLKTSVFIEV EGAAHYLPAY AGNLDIMTSA 

       310 
ALATAERMAA SLVNA 

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia phymatum STM815."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Bruce D., Goodwin L., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Bacher J., Blanchard J., Cohan F., James E., Lawrence J., Lizotte-Waniewski M., Moulin L., Rainey P., Riley M., Souza V., Wertz J., Young P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17167 / STM815.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001044 Genomic DNA. Translation: ACC73650.1.
RefSeqYP_001860696.1. NC_010623.1.

3D structure databases

ProteinModelPortalB2JQV9.
SMRB2JQV9. Positions 5-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391038.Bphy_4538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC73650; ACC73650; Bphy_4538.
GeneID6246057.
KEGGbph:Bphy_4538.
PATRIC19195819. VBIBurPhy25146_4796.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMATSAGAHR.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycBPHY391038:GI4Z-4612-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_BURP8
AccessionPrimary (citable) accession number: B2JQV9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families