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B2JQV9

- ACDH2_BURP8

UniProt

B2JQV9 - ACDH2_BURP8

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Protein

Acetaldehyde dehydrogenase 2

Gene

Bphy_4538

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Acyl-thioester intermediateUniRule annotation
Binding sitei293 – 2931NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NADUniRule annotation
Nucleotide bindingi166 – 1749NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-4612-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:Bphy_4538
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Acetaldehyde dehydrogenase 2PRO_1000187028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_4538.

Structurei

3D structure databases

ProteinModelPortaliB2JQV9.
SMRiB2JQV9. Positions 5-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B2JQV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATDNTKRKA AIIGSGNIGT DLMIKIMRRS RHLDVAAMVG IDPASDGLAR
60 70 80 90 100
AAKLGVATTH EGVQGLTRLS VFDEIDFVFD ATSAGAHVKN DAFLRTLKPG
110 120 130 140 150
IRVIDLTPAA IGPYCVPVVN LDAHLDAPNV NMVTCGGQAT IPMVAAVSRV
160 170 180 190 200
AKVHYAEIVA SISSRSAGPG TRANIDEFTE TTSKAIEAVG GAGKGKAIIV
210 220 230 240 250
LNPAEPPLMM RDTVYVLSEA ADRAQIEASV ERMAAAVQAY VPGYRLKQSV
260 270 280 290 300
QFDDIPANAP LHIPGLGRFS GLKTSVFIEV EGAAHYLPAY AGNLDIMTSA
310
ALATAERMAA SLVNA
Length:315
Mass (Da):32,933
Last modified:June 10, 2008 - v1
Checksum:iFA0E11697D678AA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC73650.1.
RefSeqiWP_012403822.1. NC_010623.1.
YP_001860696.1. NC_010623.1.

Genome annotation databases

EnsemblBacteriaiACC73650; ACC73650; Bphy_4538.
GeneIDi6246057.
KEGGibph:Bphy_4538.
PATRICi19195819. VBIBurPhy25146_4796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001044 Genomic DNA. Translation: ACC73650.1 .
RefSeqi WP_012403822.1. NC_010623.1.
YP_001860696.1. NC_010623.1.

3D structure databases

ProteinModelPortali B2JQV9.
SMRi B2JQV9. Positions 5-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_4538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC73650 ; ACC73650 ; Bphy_4538 .
GeneIDi 6246057.
KEGGi bph:Bphy_4538.
PATRICi 19195819. VBIBurPhy25146_4796.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BPHY391038:GI4Z-4612-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiACDH2_BURP8
AccessioniPrimary (citable) accession number: B2JQV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3