B2JQI5 (KHSE_BURP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bphy_4412

Organism

Burkholderia phymatum (strain DSM 17167 / STM815) [Complete proteome] [HAMAP]

Taxonomic identifier

391038 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Homoserine kinase HAMAP MF_00301		PRO_1000115429

Sequences

	Sequence		Length	Mass (Da)
	B2JQI5 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 1F251463806E68F6	FASTA	323	36,317
	10 20 30 40 50 60 MAVFTAVTEA QLADWMRHYD LGEVVEFRGI TSGIENSNFF LTTTRGEYVL TIFEKLTAQQ 70 80 90 100 110 120 LPFYLDLMRH LASHRVPVPD PMPRDDGALF GMLNGKPATI VTKLDGAPEL APGAAHCVEV 130 140 150 160 170 180 GQMLARLHLA GRDFAHHQPN LRSLPWWQET VPSIAPFLSD ARRTLLTEEL AHQQAFFASA 190 200 210 220 230 240 DYASLPGGPC HCDLFRDNVL FAHAAPGTHH EVELGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGKLDE ARVEAMLRAY QTVRPFTPAE ARHWGDMLRA GAYRFWVSRL YDFHMPRAAE 310 320 LLKPHDPGHF ERILRERLAG AAL

References

[1]

"Complete sequence of chromosome 2 of Burkholderia phymatum STM815." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Bruce D., Goodwin L., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Bacher J., Blanchard J., Cohan F., James E., Lawrence J., Lizotte-Waniewski M., Moulin L., Rainey P., Riley M., Souza V., Wertz J., Young P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17167 / STM815.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001044 Genomic DNA. Translation: ACC73526.1.
RefSeq	YP_001860572.1. NC_010623.1.
3D structure databases
ProteinModelPortal	B2JQI5.
ModBase	Search...
Protein-protein interaction databases
STRING	B2JQI5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6245933.
GenomeReviews	Gene locus Bphy_4412 in contig CP001044_GR.
KEGG	bph:Bphy_4412.
PATRIC	19195555. VBIBurPhy25146_4664.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURP8

Accession

Primary (citable) accession number: B2JQI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program