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B2JPR0 (B2JPR0_BURP8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH2 HAMAP MF_00191
Ordered Locus Names:Bphy_4130
OrganismBurkholderia phymatum (strain DSM 17167 / STM815) [Complete proteome] [HAMAP]
Taxonomic identifier391038 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B2JPR0 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 080299681213B0E0

FASTA31433,907
        10         20         30         40         50         60 
MRVILAQPRG FCAGVVRAIE IVDRALQQHG APVYVRHEIV HNRHVVDNLR QKGARFVEEL 

        70         80         90        100        110        120 
DEVPQGAVAI FSAHGVSQSV ERDAEQRGLD VLDATCPLVT KVHVQGRQYV AGGRTLILIG 

       130        140        150        160        170        180 
HAGHPEVEGT IGQIPGKVLL VQSEAEVAQL ELPIDTPLAY VTQTTLSVDD TRGIINALKR 

       190        200        210        220        230        240 
RFPDIVGPDT RDICYATQNR QAAVRELSSQ VDVLLVVGAT NSSNSNRLRE IGSESGVPSY 

       250        260        270        280        290        300 
LVADGSEIKP EWFANVTTVG ITAGASAPEE MVENVIDALR ALGPVDVTTM AGREEKVEFK 

       310 
LPSKLTQPLA AREV

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia phymatum STM815."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Bruce D., Goodwin L., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Bacher J., Blanchard J., Cohan F., James E., Lawrence J., Lizotte-Waniewski M., Moulin L., Rainey P., Riley M., Souza V., Wertz J., Young P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001044 Genomic DNA. Translation: ACC73251.1.
RefSeqYP_001860297.1. NC_010623.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2JPR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6245658.
GenomeReviewsGene locus Bphy_4130 in contig CP001044_GR.
KEGGbph:Bphy_4130.
PATRIC19194947. VBIBurPhy25146_4360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2JPR0_BURP8
AccessionPrimary (citable) accession number: B2JPR0
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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