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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Bphy_3947
OrganismiParaburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001192 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003720251 – 268GTP cyclohydrolase FolE2Add BLAST268

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_3947.

Structurei

3D structure databases

ProteinModelPortaliB2JP67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.
OrthoDBiPOG091H0MIO.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2JP67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQMNPAFVM PDVQSTVDTR QIPIQRVGVK AVRHPLTVRT PDGSAQPTVG
60 70 80 90 100
TWNLDVHLPA EVKGTHMSRF VALLEENKAP LDSSAFRALL TSMLEKLEAP
110 120 130 140 150
AGRIEVSFPY FVNKTAPVSG VQSLLDYEVS LMGDSRDGAT RLFLKVLVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTINAELID DVPVEDLIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA QRLNDDHRIV AYVLEAENFE
260
SIHNHSAYAV IESDKRLR
Length:268
Mass (Da):30,032
Last modified:June 10, 2008 - v1
Checksum:i9F0C46D021A72010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001044 Genomic DNA. Translation: ACC73070.1.
RefSeqiWP_012403243.1. NC_010623.1.

Genome annotation databases

EnsemblBacteriaiACC73070; ACC73070; Bphy_3947.
GeneIDi27743602.
KEGGibph:Bphy_3947.
PATRICi19194553. VBIBurPhy25146_4163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001044 Genomic DNA. Translation: ACC73070.1.
RefSeqiWP_012403243.1. NC_010623.1.

3D structure databases

ProteinModelPortaliB2JP67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391038.Bphy_3947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC73070; ACC73070; Bphy_3947.
GeneIDi27743602.
KEGGibph:Bphy_3947.
PATRICi19194553. VBIBurPhy25146_4163.

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.
OrthoDBiPOG091H0MIO.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCH4_PARP8
AccessioniPrimary (citable) accession number: B2JP67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.