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Protein

NAD(P)H dehydrogenase (quinone)

Gene

Bphy_3669

Organism
Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12NAD(P)UniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei134FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FMNUniRule annotation6
Nucleotide bindingi78 – 80FMNUniRule annotation3
Nucleotide bindingi113 – 119FMNUniRule annotation7

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPHY391038:G1GBS-3764-MONOMER

Protein family/group databases

CAZyiAA6 Auxiliary Activities 6

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:Bphy_3669
OrganismiParaburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001192 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002006201 – 199NAD(P)H dehydrogenase (quinone)Add BLAST199

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_3669

Structurei

3D structure databases

ProteinModelPortaliB2JML0
SMRiB2JML0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 190Flavodoxin-likeUniRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS1 Bacteria
COG0655 LUCA
HOGENOMiHOG000030539
KOiK03809
OMAiVGVPYAC
OrthoDBiPOG091H03V0

Family and domain databases

Gene3Di3.40.50.360, 1 hit
HAMAPiMF_01017 NQOR, 1 hit
InterProiView protein in InterPro
IPR008254 Flavodoxin/NO_synth
IPR029039 Flavoprotein-like_sf
IPR010089 Flavoprotein_WrbA-like
IPR005025 FMN_Rdtase-like
IPR037513 NQO
PfamiView protein in Pfam
PF03358 FMN_red, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit
TIGRFAMsiTIGR01755 flav_wrbA, 1 hit
PROSITEiView protein in PROSITE
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

B2JML0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVLVLYYS SYGHIEKMAE AIAEGARGAG AQVDIKRVPE TVPEEIAKKA
60 70 80 90 100
NFKLDQQAPI ATVADLEQYD AIVVGTGTRY GRISSQMAAF LDQTGGLWMR
110 120 130 140 150
GALNGKVGAA FASTATQHGG QETTLFSIIT NLMHLGMIIV GLPYSHQGMM
160 170 180 190
NMTEIVGGAP YGATTIAAGD GSRQPSAIDL EGARHQGELV AKTAAKLFG
Length:199
Mass (Da):20,943
Last modified:June 10, 2008 - v1
Checksum:iA0572B4A47EC48F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001044 Genomic DNA Translation: ACC72804.1
RefSeqiWP_012402977.1, NC_010623.1

Genome annotation databases

EnsemblBacteriaiACC72804; ACC72804; Bphy_3669
GeneIDi27743335
KEGGibph:Bphy_3669

Similar proteinsi

Entry informationi

Entry nameiNQOR_PARP8
AccessioniPrimary (citable) accession number: B2JML0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health