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B2JLM7

- ACDH1_BURP8

UniProt

B2JLM7 - ACDH1_BURP8

Protein

Acetaldehyde dehydrogenase 1

Gene

Bphy_3511

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321Acyl-thioester intermediateUniRule annotation
    Binding sitei291 – 2911NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADUniRule annotation
    Nucleotide bindingi163 – 1719NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBPHY391038:GI4Z-3580-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Ordered Locus Names:Bphy_3511
    OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
    Taxonomic identifieri391038 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001192: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Acetaldehyde dehydrogenase 1PRO_0000387632Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391038.Bphy_3511.

    Structurei

    3D structure databases

    ProteinModelPortaliB2JLM7.
    SMRiB2JLM7. Positions 1-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiSIYLEIE.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2JLM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRKLKVAII GSGNIGTDLM IKILRHGEHI EMGAMVGIDA ASDGLQRAAR    50
    LGVVTTHEGV EGLSRMPVFA DIDIVFDATS ASAHTRNDAF LRAIKPGIRF 100
    VDLTPAAIGP YCIPVVNGER HLDAPNVNMV TCGGQATIPM VAAVSRVARV 150
    RYAEIVASIS SRSAGPGTRA NIDEFTETTS RAIEVVGGAA VGKAIIVLNP 200
    AEPPLIMRDT VYTLSEFVDE RQIEESVTRM AEAVQTYVPG YRLKQRVQFD 250
    RIDADGPIRI PGISDRMVGL KTSIYLEIEG AAHYLPAYAG NLDIMTSAAK 300
    VTAEGVANRL LANKK 315
    Length:315
    Mass (Da):33,735
    Last modified:June 10, 2008 - v1
    Checksum:iAEC1AD8E3A407252
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC72660.1.
    RefSeqiYP_001859706.1. NC_010623.1.

    Genome annotation databases

    EnsemblBacteriaiACC72660; ACC72660; Bphy_3511.
    GeneIDi6245067.
    KEGGibph:Bphy_3511.
    PATRICi19193633. VBIBurPhy25146_3709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001044 Genomic DNA. Translation: ACC72660.1 .
    RefSeqi YP_001859706.1. NC_010623.1.

    3D structure databases

    ProteinModelPortali B2JLM7.
    SMRi B2JLM7. Positions 1-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391038.Bphy_3511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC72660 ; ACC72660 ; Bphy_3511 .
    GeneIDi 6245067.
    KEGGi bph:Bphy_3511.
    PATRICi 19193633. VBIBurPhy25146_3709.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi SIYLEIE.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BPHY391038:GI4Z-3580-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17167 / STM815.

    Entry informationi

    Entry nameiACDH1_BURP8
    AccessioniPrimary (citable) accession number: B2JLM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3