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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64Substrate1
Binding sitei139Substrate1
Binding sitei199Substrate1
Binding sitei229Substrate1
Binding sitei233Substrate1
Binding sitei234NAD1
Binding sitei286NAD1
Binding sitei321NAD1
Binding sitei387NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 202NAD3
Nucleotide bindingi263 – 268NAD6
Nucleotide bindingi342 – 344NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:Bphy_2918
OrganismiParaburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) (Burkholderia phymatum)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001192 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001292731 – 473AdenosylhomocysteinaseAdd BLAST473

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_2918.

Structurei

3D structure databases

ProteinModelPortaliB2JIP4.
SMRiB2JIP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2JIP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAVIDSKH SQDFIVADLS LADWGRKELD IAETEMPGLV QIREEYKAQQ
60 70 80 90 100
PLKGARVAGS LHMTIQTGVL IETLKALGAD VRWASCNIFS TQDHAAAAIA
110 120 130 140 150
KGGTPVFAFK GESLDEYWEF SHRIFEWPNG EFANMILDDG GDATLLLILG
160 170 180 190 200
SKAEKDRSVI SKPTNEEEVA LYKSIARHLD ADPVWYSTRL AHIKGVTEET
210 220 230 240 250
TTGVHRLYQM EKEGRLPFPA INVNDSVTKS KFDNLYGCRE SLVDGIKRAT
260 270 280 290 300
DVMIAGKIAV VAGYGDVGKG CAQSLRGLGA TVWVTEIDPI CALQAAMEGY
310 320 330 340 350
RVVTMEYAAD KADIFVTATG NYHVIGHDHM KAMRHNAIVC NIGHFDSEID
360 370 380 390 400
VASTRQYTWE NIKPQVDHII FPDGKRVILL AEGRLVNLGC ATGHPSFVMS
410 420 430 440 450
NSFTNQTLAQ IELFVEGSKY ENKVYVLPKQ LDEKVARLHL ARIGANLTEL
460 470
TSEQAGYIGV DKNGPFKPNH YRY
Length:473
Mass (Da):52,204
Last modified:June 10, 2008 - v1
Checksum:i25B794C3CE5D44FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001043 Genomic DNA. Translation: ACC72090.1.
RefSeqiWP_012402269.1. NC_010622.1.

Genome annotation databases

EnsemblBacteriaiACC72090; ACC72090; Bphy_2918.
GeneIDi27742619.
KEGGibph:Bphy_2918.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PARP8
AccessioniPrimary (citable) accession number: B2JIP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families