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B2JIB3

- LPXB_BURP8

UniProt

B2JIB3 - LPXB_BURP8

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Bphy_1325
Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-1356-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Bphy_1325
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_1325.

Structurei

3D structure databases

ProteinModelPortaliB2JIB3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B2JIB3-1 [UniParc]FASTAAdd to Basket

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MPLPTSPLRL AMVAGEPSGD LLAASMLDGL AARLPDTTQY FGIGGPRMIA    50
KGFDAHFAME KLSVRGYVEA LKHVPEILGI RNELKRQLLA EPPSAFIGVD 100
APDFNFGLEH PLRDAGIPTI HFVCPSIWAW RGGRIKKIVK AVDHMLCVFP 150
FEKALLEKSG VTATYVGHPL ADEIPLEPDT AGARLELGLP ESGPVIAVLP 200
GSRRSEIALI GPTFFDAMEL MLQREPGVRF VMPAATPALR ELLKPLVDAH 250
ANLPLTLTDG NAQRAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
GQIMRRQGYL PYVGLPNILA GRFVVPEILQ HFATPEALAD ATLTQLRDDA 350
NRRTLTEIFT EMHHVLKQNT AQRAAEAVVG VIEARRGRP 389
Length:389
Mass (Da):42,289
Last modified:June 10, 2008 - v1
Checksum:i8EBA7A370C6313E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001043 Genomic DNA. Translation: ACC70507.1.
RefSeqiWP_012400721.1. NC_010622.1.
YP_001857553.1. NC_010622.1.

Genome annotation databases

EnsemblBacteriaiACC70507; ACC70507; Bphy_1325.
GeneIDi6242816.
KEGGibph:Bphy_1325.
PATRICi19188952. VBIBurPhy25146_1408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001043 Genomic DNA. Translation: ACC70507.1 .
RefSeqi WP_012400721.1. NC_010622.1.
YP_001857553.1. NC_010622.1.

3D structure databases

ProteinModelPortali B2JIB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_1325.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC70507 ; ACC70507 ; Bphy_1325 .
GeneIDi 6242816.
KEGGi bph:Bphy_1325.
PATRICi 19188952. VBIBurPhy25146_1408.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BPHY391038:GI4Z-1356-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiLPXB_BURP8
AccessioniPrimary (citable) accession number: B2JIB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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