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B2JGX6

- SYL_BURP8

UniProt

B2JGX6 - SYL_BURP8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPHY391038:GI4Z-2640-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Bphy_2588
    OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
    Taxonomic identifieri391038 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001192: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_1000091300Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391038.Bphy_2588.

    Structurei

    3D structure databases

    ProteinModelPortaliB2JGX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2JGX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHEKYVPSDV ESAAQGQWRA TDAYKTTETA DKPKFYCVSM LPYPSGKLHM    50
    GHVRNYTIND VMYRYLRMNG YNTLMPMGWD AFGMPAENAA MANGVPPAKW 100
    TYDNIAYMKK QMQSMGLAID WSREVATCSP DYYKWNQWIF LKMLEKGIAY 150
    KKTGTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKREIPM YYMRITQYAD 200
    ELLNDLDGLG WPERVKVMQQ NWIGKSFGVN FGFPYELDGE QKLLRVFTTR 250
    ADTIMGVTFC AVAAEHPLAT RLAQGRPDLQ SFIDECKHGG VAEADMATME 300
    KKGMATGFFV THPLTQEKVE VWIGNYVLMS YGEGAVMGVP AHDERDFAFV 350
    KKYGIPVKQV VAVEGETFST DAWQESYGDK ENGVLINSGK YDGLKYGEAV 400
    DAIAADLKAL GLGEKQVTWR LRDWGISRQR YWGTPIPIIH CPSCGDVPVP 450
    EKDLPVVLPE DLVPDGTGNP LAKSEAFLNC TCPTCGAAAK RETDTMDTFV 500
    DSSWYFYRYA APDAKTMVDA RTDYWMPMDQ YIGGIEHAIL HLLYSRFWAK 550
    VCRDLGIVKF GEPAKNLLTQ GMVLNETYYR ENDAGKKTWY NPADVTVTHD 600
    DKGRPVGATL NADGQPVVLG GVEKMSKSKN NGVDPQVLID QYGADTARLF 650
    TMFAAPPEQQ LEWSGAGVEG ASRFLRRVWA FGQANETALT ERAPFDAAKL 700
    ADTEKTLRRE IYSVLKQADF DYQRLQYNTV VSAAMKMLNA IEGAKGASAA 750
    VLRETYGVLL RVLYPVVPHV TFQLWRELGY EGEFGSLLDA PWPKVDEKAL 800
    EQSEIELVLQ VNGKVRGAVT VAKDASREAI EAVALAHEMF AKFSEGKPAK 850
    KVIVVPGRLV NVVV 864
    Length:864
    Mass (Da):96,522
    Last modified:June 10, 2008 - v1
    Checksum:i4D68B9ABCB2DFD12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001043 Genomic DNA. Translation: ACC71760.1.
    RefSeqiYP_001858806.1. NC_010622.1.

    Genome annotation databases

    EnsemblBacteriaiACC71760; ACC71760; Bphy_2588.
    GeneIDi6244071.
    KEGGibph:Bphy_2588.
    PATRICi19191671. VBIBurPhy25146_2746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001043 Genomic DNA. Translation: ACC71760.1 .
    RefSeqi YP_001858806.1. NC_010622.1.

    3D structure databases

    ProteinModelPortali B2JGX6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391038.Bphy_2588.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC71760 ; ACC71760 ; Bphy_2588 .
    GeneIDi 6244071.
    KEGGi bph:Bphy_2588.
    PATRICi 19191671. VBIBurPhy25146_2746.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BPHY391038:GI4Z-2640-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17167 / STM815.

    Entry informationi

    Entry nameiSYL_BURP8
    AccessioniPrimary (citable) accession number: B2JGX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3