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B2JGE9

- NADK_BURP8

UniProt

B2JGE9 - NADK_BURP8

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Protein
NAD kinase
Gene
nadK, Bphy_2504
Organism
Burkholderia phymatum (strain DSM 17167 / STM815)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Proton acceptor By similarity
Binding sitei177 – 1771NAD By similarity
Binding sitei179 – 1791NAD By similarity
Binding sitei214 – 2141NAD; via carbonyl oxygen By similarity
Binding sitei248 – 2481NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 762NAD By similarity
Nucleotide bindingi149 – 1502NAD By similarity
Nucleotide bindingi190 – 1956NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPHY391038:GI4Z-2555-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Bphy_2504
OrganismiBurkholderia phymatum (strain DSM 17167 / STM815)
Taxonomic identifieri391038 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001192: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300NAD kinaseUniRule annotation
PRO_1000120836Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391038.Bphy_2504.

Structurei

3D structure databases

ProteinModelPortaliB2JGE9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B2JGE9-1 [UniParc]FASTAAdd to Basket

« Hide

MQANSQFKTV ALVGRSNTPG IGEPLTALAT CIEKLGFEIA FEAETAQEIG    50
VSRWPALQPA EIGARADVAI VLGGDGTMLG IGRQLAPYKT PLIGINHGRL 100
GFITDIPFSD MREIIPQMLS GSFEREERSL LESRIMRDGQ PIYHALAFND 150
VVVNRSGFSG MAELRVSVDG RFMYNQRSDG LIVATPTGST AYALSSQGPI 200
LHPQLQGLVL VPIAPHALSN RPIVIPDDSK VSIQIISGRD VNVNFDMQSF 250
TALELNDTID VRRSRHTVPF LHPVGYSYYA TLRKKLHWNE YPSHEDDPDD 300
Length:300
Mass (Da):32,939
Last modified:June 10, 2008 - v1
Checksum:i18F48BC00512A61E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001043 Genomic DNA. Translation: ACC71677.1.
RefSeqiWP_012401881.1. NC_010622.1.
YP_001858723.1. NC_010622.1.

Genome annotation databases

EnsemblBacteriaiACC71677; ACC71677; Bphy_2504.
GeneIDi6243988.
KEGGibph:Bphy_2504.
PATRICi19191495. VBIBurPhy25146_2658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001043 Genomic DNA. Translation: ACC71677.1 .
RefSeqi WP_012401881.1. NC_010622.1.
YP_001858723.1. NC_010622.1.

3D structure databases

ProteinModelPortali B2JGE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391038.Bphy_2504.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC71677 ; ACC71677 ; Bphy_2504 .
GeneIDi 6243988.
KEGGi bph:Bphy_2504.
PATRICi 19191495. VBIBurPhy25146_2658.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BPHY391038:GI4Z-2555-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17167 / STM815.

Entry informationi

Entry nameiNADK_BURP8
AccessioniPrimary (citable) accession number: B2JGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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