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Reviewed, UniProtKB/Swiss-Prot B2JGE7 (HEMH_BURP8)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase
Gene names
Name: hemH
Ordered Locus Names: Bphy_2502
OrganismBurkholderia phymatum (strain DSM 17167 / STM815) [Complete proteome] [HAMAP]
Taxonomic identifier391038 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

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Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity.

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ferrochelatase family.

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Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Ferrochelatase HAMAP MF_00323
PRO_1000116034

Sites

Metal binding2141Iron By similarity
Metal binding2951Iron By similarity

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Sequences

Sequence LengthMass (Da)Tools
B2JGE7-1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0A14B29F7107E40F

FASTA35639,514
        10         20         30         40         50         60 
MRFDLERPLQ SAAAHRVAVL LINLGTPDAP TPRAVRRYLA QFLSDPRVVE IPSLVWQIIL 

        70         80         90        100        110        120 
RLFILPFRGV ASAKKYASVW MPEGSPLRVH TQKQVEGLRH LLHLNDYTVI VEYAMRYGTP 

       130        140        150        160        170        180 
DIPAMLNQLK LAGAERILLM PMYPQYSAST TATAFDAAFV ALRRMRNQPE IRTVRQYADH 

       190        200        210        220        230        240 
PAYIAALAAQ VNHYWHAHGR PDFAAGDKLV LSFHGVPKRT LDLGDPYHDQ CQQTATLLMH 

       250        260        270        280        290        300 
ALGLTSVECR VTFQSRFGKA EWLQPYTAPT LKELGAAGVH RADVFCPGFT ADCLETIEEI 

       310        320        330        340        350 
GMEVRDEFLH AGGKVFHAIP CLNAAPAWIA ALGEIVAQHL QGWPVQAATP QSASVA

« Hide

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References

[1]"Complete sequence of chromosome 1 of Burkholderia phymatum STM815."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Bruce D., Goodwin L., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Bacher J., Blanchard J., Cohan F., James E., Lawrence J., Lizotte-Waniewski M., Moulin L., Rainey P., Riley M., Souza V., Wertz J., Young P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001043 Genomic DNA. Translation: ACC71675.1.
RefSeqYP_001858721.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6243986.
GenomeReviewsGene locus Bphy_2502 in contig CP001043_GR.
KEGGbph:Bphy_2502.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMATIEEIGM.

Family and domain databases

HAMAPMF_00323.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHEMH_BURP8
AccessionPrimary (citable) accession number: B2JGE7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents