B2JDS4 (KYNB_BURP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
Short name=KFase
EC=3.5.1.9

Alternative name(s):
Arylformamidase
N-formylkynurenine formamidase
Short name=FKF

Gene names

Name:	kynB
Ordered Locus Names:	Bphy_0508

Organism

Burkholderia phymatum (strain DSM 17167 / STM815) [Complete proteome] [HAMAP]

Taxonomic identifier

391038 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia phymatum

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation By similarity. HAMAP-Rule MF_01969
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine. HAMAP-Rule MF_01969
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. HAMAP-Rule MF_01969
Sequence similarities	Belongs to the KynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase HAMAP-Rule MF_01969		PRO_0000362113

Sequences

	Sequence		Length	Mass (Da)
	B2JDS4 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: A7F8D624DBB8D933	FASTA	209	22,409
	10 20 30 40 50 60 MDTLWDITPA VDTATPVWPG DTPVGIERVW RMEAGSPVNV ARLTMSPHTG AHTDAPLHYD 70 80 90 100 110 120 AGGVAIGAVP LDSYLGRCRV IHCIGVKPLV MPDDLAGSLD GVPPRVLLRT YREAPTTFWD 130 140 150 160 170 180 SGFCAVAPET IDLLAARGVK LIGIDTPSLD PQESKTMDAH HRIRAHRMAI LEGIVLDAVA 190 200 PGDYELIALP LKLSTLDASP VRAVLRSLT

References

[1]

"Complete sequence of chromosome 1 of Burkholderia phymatum STM815." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Bruce D., Goodwin L., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Bacher J., Blanchard J., Cohan F., James E., Lawrence J., Lizotte-Waniewski M., Moulin L., Rainey P., Riley M., Souza V., Wertz J., Young P. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17167 / STM815.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001043 Genomic DNA. Translation: ACC69700.1.
RefSeq	YP_001856746.1. NC_010622.1.
3D structure databases
ProteinModelPortal	B2JDS4.
ModBase	Search...
Protein-protein interaction databases
STRING	391038.Bphy_0508.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACC69700; ACC69700; Bphy_0508.
GeneID	6242009.
KEGG	bph:Bphy_0508.
PATRIC	19187155. VBIBurPhy25146_0533.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HOG000219455.
KO	K07130.
OMA	NGRIFDI.
ProtClustDB	CLSK930430.
Enzyme and pathway databases
BioCyc	BPHY391038:GI4Z-5233-MONOMER.
UniPathway	UPA00333; UER00454.
Family and domain databases
HAMAP	MF_01969. KynB.
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURP8

Accession

Primary (citable) accession number: B2JDS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program