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B2J9P0 (HEMH_NOSP7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Npun_F2510
OrganismNostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]
Taxonomic identifier63737 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ferrochelatase HAMAP MF_00323
PRO_1000116062

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2J9P0 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 4A08C1C3DC9832FD

FASTA38844,243
        10         20         30         40         50         60 
MGRVGVLLLN LGGPDKLEDV GPFLYNLFSD PEIIRLPFRW LQKPLAWFIA SRRTRTSQQN 

        70         80         90        100        110        120 
YKQIGGGSPL RRITEAQGEA LKKQLGYLGQ EANIYVGMRY WHPYTEEAIA QITQDNIEHL 

       130        140        150        160        170        180 
VILPLYPQFS ISTSGSSFRL LDKLWQEEPK LQPIEYTVIP SWYKQPGYLQ AMAELIAQEL 

       190        200        210        220        230        240 
EQFPNPDEVH IFFSAHGVPK SYVEEAGDPY QQEIEECTAL IMQTLNRPNA HTLAYQSRVG 

       250        260        270        280        290        300 
PVEWLQPYTE DALKELGAQG VKDLVVVPIS FVSEHIETLQ EIDIEYREVA EESGIHNFRR 

       310        320        330        340        350        360 
VPAPNTHPVF INALAELVID ALKNPSFKLS QAAQMKKMVK MYPQERWEWG LTTSAEVWNG 

       370        380 
RIAMLGFIAL IIELITGHGF LHMIGLLQ

« Hide

References

[1]"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. expand/collapse author list , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001037 Genomic DNA. Translation: ACC81067.1.
RefSeqYP_001866010.1. NC_010628.1.

3D structure databases

ProteinModelPortalB2J9P0.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2J9P0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6251906.
GenomeReviewsGene locus Npun_F2510 in contig CP001037_GR.
KEGGnpu:Npun_F2510.
PATRIC22757459. VBINosPun48114_2920.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALQKPLAW.
PhylomeDBB2J9P0.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR023329. Chlorophyll_a/b-bd_dom.
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
SUPFAMSSF103511. SSF103511. 1 hit.
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_NOSP7
AccessionPrimary (citable) accession number: B2J9P0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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