B2J8X0 (B2J8X0_NOSP7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE HAMAP MF_00222
Ordered Locus Names:	Npun_R4233

Organism

Nostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]

Taxonomic identifier

63737 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ACC82608.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	136 – 140	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B2J8X0 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: E9CF9D1744AE03AD	FASTA	295	32,011
	10 20 30 40 50 60 MANDKLITGK TKLLGVIGHP VEHSLSPAMH NAAIANLGLD YVYLPFPIAP ENLEVAIAGF 70 80 90 100 110 120 AVIGVVGFSV TIPHKQAIMP LLSEITPLAQ MIGAVNTVSR QNNQWVGTNT DIEGFIAPLQ 130 140 150 160 170 180 TTYKQDWSQK VAVILGNGGA ARAVVAGCHQ LGFAKIHVVG RNVQRLQEFR DSWSNSPISE 190 200 210 220 230 240 NLQVHQWEEL SKLIPQANLL VNTTPIGMYP KVDESPLSIE EIANLPTGAI AYDLIYIPKP 250 260 270 280 290 TQFLELAQKQ GAIAIDGLEM LVQQGVAALK IWLQQENIPV EVMRQALLNQ LGLGK

References

[1]

"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001037 Genomic DNA. Translation: ACC82608.1.
RefSeq	YP_001867551.1. NC_010628.1.
3D structure databases
ProteinModelPortal	B2J8X0.
ModBase	Search...
Protein-protein interaction databases
STRING	B2J8X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6253577.
GenomeReviews	Gene locus Npun_R4233 in contig CP001037_GR.
KEGG	npu:Npun_R4233.
PATRIC	22761628. VBINosPun48114_4973.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	AYDLIYT.
PhylomeDB	B2J8X0.
ProtClustDB	PRK00258.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2J8X0_NOSP7

Accession

Primary (citable) accession number: B2J8X0

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)