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B2J7T9

- SYL_NOSP7

UniProt

B2J7T9 - SYL_NOSP7

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Protein

Leucine--tRNA ligase

Gene
leuS, Npun_F4156
Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-4025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Npun_F4156
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Leucine--tRNA ligaseUniRule annotationPRO_1000091339Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_F4156.

Structurei

3D structure databases

ProteinModelPortaliB2J7T9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi634 – 6385"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.
PhylomeDBiB2J7T9.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2J7T9-1 [UniParc]FASTAAdd to Basket

« Hide

MDSRYNPAAI EEKRQKTWLE LGLDKTPSAS NKPKFYALSM FPYPSGSLHM    50
GHVRNYTITD VIARFKRMQG YRVIHPMGWD AFGLPAENAA IDRGVPPAKW 100
TYQNITQMRQ QLQRLGLSID WECELATCSP DYYKWTQWIF LQFLQAGLAY 150
QKEAAVNWDP IDQTVLANEQ VDNEGRSWRS GAIVERKLLR QWFFKITDYA 200
EELLNDLDKL TGWPERVKLM QANWIGKSTG AYLEFPIVGI DEKIAVYTTR 250
PDTVYGVSYL VLAPEHPLTN RVTTKEQQAA VEVFIKEVSN QSELERTSED 300
KPKRGIPTGG VAINPFTGEE VPIWIADYVL YEYGTGAVMG VPAHDVRDFK 350
FAKNYDLPIN FVIASPDDVA GFDLTPTSEI DGITQLVEVD YKQAYTEPGI 400
LINSGAFTGI SSTDAKQAII EYAEKQDFGK VRVQYRLRDW LISRQRYWGA 450
PIPVIHCPNC GIVPVPDKDL PVQLPEEVEF TGRCGSPLTQ LESWVNVPCP 500
TCGTPAKRET DTMDTFIDSS WYFLRFPDAK NEQQVFDSSK VNDWMPVNQY 550
VGGIEHAILH LLYSRFFTKV LRDRGLLNFD EPFQRLLTQG MVQGLTYLNP 600
NKGGKDKWIP SNLVNSADPR DPQTDEPLQR LYATMSKSKG NGVAPEDVIS 650
KYGIDTARMF ILFKAPPEKD LEWDEADVEG QFRFLNRVWR LVTDYITAGV 700
SRKKAQSDLT KAEKELRRAI HTAIQAVTED VEDEYQFNTA ISELMKLSNA 750
LSDADKNSPI YAEGIRTLVI LIAPFAPHIA DELWHLLGES DSIHTQTWPS 800
FDPAALVADE ITLVIQVMGK TRGAIQVPAQ ADKAALEKYA RESEIAQRYI 850
EGKEIKKVIV VPGKLVNFVV S 871
Length:871
Mass (Da):98,573
Last modified:June 10, 2008 - v1
Checksum:iF57D19EF68173BAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82534.1.
RefSeqiYP_001867477.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82534; ACC82534; Npun_F4156.
GeneIDi6253501.
KEGGinpu:Npun_F4156.
PATRICi22761434. VBINosPun48114_4876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82534.1 .
RefSeqi YP_001867477.1. NC_010628.1.

3D structure databases

ProteinModelPortali B2J7T9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 63737.Npun_F4156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC82534 ; ACC82534 ; Npun_F4156 .
GeneIDi 6253501.
KEGGi npu:Npun_F4156.
PATRICi 22761434. VBINosPun48114_4876.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.
PhylomeDBi B2J7T9.

Enzyme and pathway databases

BioCyci NPUN63737:GJNP-4025-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiSYL_NOSP7
AccessioniPrimary (citable) accession number: B2J7T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi