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B2J7M9

- GSA_NOSP7

UniProt

B2J7M9 - GSA_NOSP7

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNPUN63737:GJNP-3965-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Npun_R4096
    OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
    Taxonomic identifieri63737 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000001191: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000121905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB2J7M9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi63737.Npun_R4096.

    Structurei

    3D structure databases

    ProteinModelPortaliB2J7M9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHGHANAF.
    OrthoDBiEOG6QVRHN.
    PhylomeDBiB2J7M9.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2J7M9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNTTIKTTK SQEVFAAAQN LMPGGVSSPV RAFKSVGGQP IVFDRVKGAY    50
    IWDVDGNQYI DYVGTWGPAI CGHAHPEVIA ALHEALEKGT SFGAPSTLEN 100
    VLAEMVIDAV PSIEMVRFVN SGTEACMGVL RLMRAFTNRD KIIKFEGCYH 150
    GHADTFLVKA GSGVATLGLP DSPGVPKAAT STTLTAPYND LESVKALFEE 200
    NRDEIAGVIL EPVVGNAGFI APDAGFLEGL RELTHEYGAL LVFDEVMTGF 250
    RIAYGGAQEK FGVTPDLTTL GKVIGGGLPV GAYGGRRDIM SMVAPAGPVY 300
    QAGTLSGNPL AMTAGIKTLE LLQKPGTYDY LERITKKLAD GLLQIAKETG 350
    HTACGGQISA MFGLFFTSGP VHNYEDAKKS DTAKFGRFHR GMLERGVYLA 400
    PSQFEAGFTS FAHTEEDIDQ TLAIARDVMS SL 432
    Length:432
    Mass (Da):45,986
    Last modified:June 10, 2008 - v1
    Checksum:iFFA9C505B06B26EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82474.1.
    RefSeqiYP_001867417.1. NC_010628.1.

    Genome annotation databases

    EnsemblBacteriaiACC82474; ACC82474; Npun_R4096.
    GeneIDi6253441.
    KEGGinpu:Npun_R4096.
    PATRICi22761296. VBINosPun48114_4807.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82474.1 .
    RefSeqi YP_001867417.1. NC_010628.1.

    3D structure databases

    ProteinModelPortali B2J7M9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 63737.Npun_R4096.

    Proteomic databases

    PRIDEi B2J7M9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC82474 ; ACC82474 ; Npun_R4096 .
    GeneIDi 6253441.
    KEGGi npu:Npun_R4096.
    PATRICi 22761296. VBINosPun48114_4807.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HGHANAF.
    OrthoDBi EOG6QVRHN.
    PhylomeDBi B2J7M9.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci NPUN63737:GJNP-3965-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29133 / PCC 73102.

    Entry informationi

    Entry nameiGSA_NOSP7
    AccessioniPrimary (citable) accession number: B2J7M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3