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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNPUN63737:G1GBR-4023-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Npun_F3940
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000001191 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei215 – 234HelicalUniRule annotationAdd BLAST20
Transmembranei238 – 257HelicalUniRule annotationAdd BLAST20
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei343 – 363HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906491 – 363Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_F3940

Structurei

3D structure databases

SMRiB2J5G4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH
PhylomeDBiB2J5G4

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2J5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKLSPEQG LNISGIALAS LLAVGLGTTA FFLDSMANRL PWQSMSLTLP
60 70 80 90 100
LLLCAMGSGV VGFWVIPLLQ ALKTGQIIRE DGPQAHLKKA GTPTMGGIFF
110 120 130 140 150
IPVGVIIACI LSNFATDVLA VSALTTSYGF IGWLDDWQIL RRKSNKGISP
160 170 180 190 200
RTKLALQVGF AAVFCLWLMF NQPSNITNIA LPWVSFTLPL GFLFWPLAGF
210 220 230 240 250
VLVAESNATN LTDGIDGLAA GTVAIALLAL GALIAPTAPG LMVFCAALSG
260 270 280 290 300
GCLGFLAHNR NPARVFMGDT GSLALGGALA AVALLTNTLV ALFILSGIFF
310 320 330 340 350
VETLSVMAQV SYYKATKGPD GKGKRLFKMA PLHHHLELTG WSELQVVGVF
360
YVIAAILAAI CLA
Length:363
Mass (Da):38,178
Last modified:June 10, 2008 - v1
Checksum:i5A0A09E23B809834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA Translation: ACC82321.1
RefSeqiWP_012410289.1, NC_010628.1

Genome annotation databases

EnsemblBacteriaiACC82321; ACC82321; Npun_F3940
KEGGinpu:Npun_F3940

Similar proteinsi

Entry informationi

Entry nameiMRAY_NOSP7
AccessioniPrimary (citable) accession number: B2J5G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health