Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Npun_F3940
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000001191 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei215 – 234HelicalUniRule annotationAdd BLAST20
Transmembranei238 – 257HelicalUniRule annotationAdd BLAST20
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei343 – 363HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906491 – 363Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_F3940.

Structurei

3D structure databases

SMRiB2J5G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.
PhylomeDBiB2J5G4.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2J5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKLSPEQG LNISGIALAS LLAVGLGTTA FFLDSMANRL PWQSMSLTLP
60 70 80 90 100
LLLCAMGSGV VGFWVIPLLQ ALKTGQIIRE DGPQAHLKKA GTPTMGGIFF
110 120 130 140 150
IPVGVIIACI LSNFATDVLA VSALTTSYGF IGWLDDWQIL RRKSNKGISP
160 170 180 190 200
RTKLALQVGF AAVFCLWLMF NQPSNITNIA LPWVSFTLPL GFLFWPLAGF
210 220 230 240 250
VLVAESNATN LTDGIDGLAA GTVAIALLAL GALIAPTAPG LMVFCAALSG
260 270 280 290 300
GCLGFLAHNR NPARVFMGDT GSLALGGALA AVALLTNTLV ALFILSGIFF
310 320 330 340 350
VETLSVMAQV SYYKATKGPD GKGKRLFKMA PLHHHLELTG WSELQVVGVF
360
YVIAAILAAI CLA
Length:363
Mass (Da):38,178
Last modified:June 10, 2008 - v1
Checksum:i5A0A09E23B809834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA. Translation: ACC82321.1.
RefSeqiWP_012410289.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82321; ACC82321; Npun_F3940.
KEGGinpu:Npun_F3940.

Similar proteinsi

Entry informationi

Entry nameiMRAY_NOSP7
AccessioniPrimary (citable) accession number: B2J5G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families