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Protein

Malate dehydrogenase

Gene

mdh

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44NADUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei186Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 25NADUniRule annotation6
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciNPUN63737:G1GBR-4017-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Npun_R3934
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000001191 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261431 – 327Malate dehydrogenaseAdd BLAST327

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_R3934

Structurei

3D structure databases

ProteinModelPortaliB2J5F8
SMRiB2J5F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6
PhylomeDBiB2J5F8

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

B2J5F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSPNSPIA CNLPRVTIVG AGRVGSTLAQ RVAEKNLADV VLLDIIAGMP
60 70 80 90 100
QGLALDLMEA RGIEIHNRQI IGTNNYADTS GSQIVVITAG LPRKPGMSRD
110 120 130 140 150
DLLKTNAKIV VEAAKNAIAH SPNAIFIVVT NPLDVMTYLA WQATGLPRDR
160 170 180 190 200
IMGMAGVLDS ARFEAFIALE LGVLPADVKA MVLGSHGDLM VPLSRYATVN
210 220 230 240 250
GIPITELLDA ATIERLIERT RNGGAEIVEL MQTGGAFFAP ASATSVMVES
260 270 280 290 300
ILLNQSRLLP VAAYLQGEYG LEDVVIGVPC RLGCGGIESV LELILSDEER
310 320
EGLHTSAQSV RQNIERSQEI LANKNNS
Length:327
Mass (Da):34,758
Last modified:June 10, 2008 - v1
Checksum:i84C6FAEE05D36B8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA Translation: ACC82315.1
RefSeqiWP_012410283.1, NC_010628.1

Genome annotation databases

EnsemblBacteriaiACC82315; ACC82315; Npun_R3934
KEGGinpu:Npun_R3934

Similar proteinsi

Entry informationi

Entry nameiMDH_NOSP7
AccessioniPrimary (citable) accession number: B2J5F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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