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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei351 – 3511UniRule annotation
Active sitei455 – 4551UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-3796-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Npun_F3925
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Glucose-6-phosphate isomerasePRO_1000125742Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_F3925.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.
PhylomeDBiB2J5F1.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2J5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARALWQRY QNWLYFHEGL GLYLDISRMR FDDAFVESLQ PKFDKAFADM
60 70 80 90 100
AELEKGAIAN PDENRMVGHY WLRNPDLAPT PELTQEIVQT LEQIEAFAEK
110 120 130 140 150
VQTGAIHPPR ASRFTDIISI GIGGSALGPQ FVAEALAPDF PPLKIHFIDN
160 170 180 190 200
NDPAGIDRVL NHLRNSLAST LVLVISKSGG TPEPRNGMIE VKKAYAGHNL
210 220 230 240 250
EFAQYAVAIT SVDSNLDKLA KDEGWLARFP MYDWVGGRTS EMSAVGLVPA
260 270 280 290 300
ALQGIDVRAM LDGAKEMDDA TRVPDVKNNP AALLALSWYF AGNGKGEKDM
310 320 330 340 350
VVLPYKDSLF LFSRYLQQLV MESLGKEKDL DGNVVHQGIA VYGNKGSTDQ
360 370 380 390 400
HAYVQQLREG VANFFATFVE VLEDRQGPST EIDPGVTSGD YLSGFLQGTR
410 420 430 440 450
QALYENHRDS ITVTIPQVNP RTVGALIALY ERAVGLYASL VNVNAYHQPG
460 470 480 490 500
VEAGKKAAAS ILDLQTRVVA VLQKEKTPIS LDELAKKAGA SDQIEAIYKI
510 520
LRHIHANQRG VVLQGDLHKP GSLTVSAS
Length:528
Mass (Da):57,927
Last modified:June 10, 2008 - v1
Checksum:iA7D282B86C5E5774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA. Translation: ACC82308.1.
RefSeqiWP_012410277.1. NC_010628.1.
YP_001867251.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82308; ACC82308; Npun_F3925.
KEGGinpu:Npun_F3925.
PATRICi22760892. VBINosPun48114_4605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA. Translation: ACC82308.1.
RefSeqiWP_012410277.1. NC_010628.1.
YP_001867251.1. NC_010628.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi63737.Npun_F3925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC82308; ACC82308; Npun_F3925.
KEGGinpu:Npun_F3925.
PATRICi22760892. VBINosPun48114_4605.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000131425.
KOiK01810.
OMAiRQVGHYW.
OrthoDBiEOG64R61J.
PhylomeDBiB2J5F1.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciNPUN63737:GJNP-3796-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiG6PI_NOSP7
AccessioniPrimary (citable) accession number: B2J5F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 27, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.