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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-3623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Npun_R3754
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Glycine dehydrogenase (decarboxylating)PRO_1000132445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei724 – 7241N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi63737.Npun_R3754.

Structurei

3D structure databases

ProteinModelPortaliB2J427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.
PhylomeDBiB2J427.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2J427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNAPILKS NEQQVLNQKS QKLSSFAPRH IGPNSDDIQQ MLKVLGFPSL
60 70 80 90 100
DALIDKTVPQ TIRLKQPLKL PEAESEYAAL ASLKKIAAKN QVFRSYIGMG
110 120 130 140 150
YYDTITPLVI GRNILENPGW YTAYTPYQPE IAQGRLEALL NFQTLIIDLT
160 170 180 190 200
GLEIANASLL DEATAAAEAM SLSYGVSKNQ ANAYFVSHDC HPQTIDVLQT
210 220 230 240 250
RAKPLGINII VGDHQTFDFD RAIFGAVLQY PASDGTIYDY RAFIEKAHAK
260 270 280 290 300
GALVTVAADP LSLTLLTPPG EFGADIAVGS TQRFGIPLGF GGPHAAYFAT
310 320 330 340 350
KEEYKRLVPG RIVGVSKDAQ GKPALRLALQ TREQHIRREK ATSNICTAQV
360 370 380 390 400
LLAVMASMYA VYHGPDGLKQ IAENIHQLTL MLAAGLKHLG YKISSEHFFD
410 420 430 440 450
TLRVELGTRS LEVILEACQA RNINLRIFDD TAVGISVDET TTADDLIELF
460 470 480 490 500
EIFAAPDSLL FGFKEIGDLI AARRKSSLQN STFARTSNYL THPVFNRYHS
510 520 530 540 550
ETELLRYLHK LESKDLSLTT SMIPLGSCTM KLNATAEMIP VTWEEFGKIH
560 570 580 590 600
PFAPASQTQG YQILFQQLEA WLAEITGFAG ISLQPNAGSQ GEYAGLLVIR
610 620 630 640 650
QYHENRGEAH RNVCLIPTSA HGTNPASAVM CGMKVVAVAC DSQGNIDVDD
660 670 680 690 700
LKAKAEKHSH ELAALMVTYP STHGVFEEPI QEICAVVHSH GGQVYMDGAN
710 720 730 740 750
MNAQVGICRP GDIGADVCHL NLHKTFCIPH GGGGPGMGPI GVASHLVPFL
760 770 780 790 800
PGHPVVTIND STQHSHIGAV AAAPWGSASI LVISWMYIAM MGADGLTQAT
810 820 830 840 850
KVAILNANYI AKKLESYYPV LYQGKNGLVA HECILDLRSL KKSAAIEIDD
860 870 880 890 900
VAKRLMDYGF HAPTVSWPVG GTIMVEPTES ESKQELDRFC DALIAIRQEI
910 920 930 940 950
AEIEVGKVDA QDNVLKNAPH TAESLITGEW QHPYSREQAA YPAPWTREYK
960 970
FWPAVGRIDA AFGDRNFVCS CLPMDAYSS
Length:979
Mass (Da):106,853
Last modified:June 10, 2008 - v1
Checksum:i7D692D6F2AE0E4E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA. Translation: ACC82139.1.
RefSeqiWP_012410110.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82139; ACC82139; Npun_R3754.
KEGGinpu:Npun_R3754.
PATRICi22760492. VBINosPun48114_4406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA. Translation: ACC82139.1.
RefSeqiWP_012410110.1. NC_010628.1.

3D structure databases

ProteinModelPortaliB2J427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi63737.Npun_R3754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC82139; ACC82139; Npun_R3754.
KEGGinpu:Npun_R3754.
PATRICi22760492. VBINosPun48114_4406.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.
PhylomeDBiB2J427.

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-3623-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiGCSP_NOSP7
AccessioniPrimary (citable) accession number: B2J427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: July 22, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.