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B2J427

- GCSP_NOSP7

UniProt

B2J427 - GCSP_NOSP7

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNPUN63737:GJNP-3623-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Npun_R3754
    OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
    Taxonomic identifieri63737 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000001191: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 979979Glycine dehydrogenase (decarboxylating)PRO_1000132445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei724 – 7241N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi63737.Npun_R3754.

    Structurei

    3D structure databases

    ProteinModelPortaliB2J427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.
    PhylomeDBiB2J427.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2J427-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLNAPILKS NEQQVLNQKS QKLSSFAPRH IGPNSDDIQQ MLKVLGFPSL    50
    DALIDKTVPQ TIRLKQPLKL PEAESEYAAL ASLKKIAAKN QVFRSYIGMG 100
    YYDTITPLVI GRNILENPGW YTAYTPYQPE IAQGRLEALL NFQTLIIDLT 150
    GLEIANASLL DEATAAAEAM SLSYGVSKNQ ANAYFVSHDC HPQTIDVLQT 200
    RAKPLGINII VGDHQTFDFD RAIFGAVLQY PASDGTIYDY RAFIEKAHAK 250
    GALVTVAADP LSLTLLTPPG EFGADIAVGS TQRFGIPLGF GGPHAAYFAT 300
    KEEYKRLVPG RIVGVSKDAQ GKPALRLALQ TREQHIRREK ATSNICTAQV 350
    LLAVMASMYA VYHGPDGLKQ IAENIHQLTL MLAAGLKHLG YKISSEHFFD 400
    TLRVELGTRS LEVILEACQA RNINLRIFDD TAVGISVDET TTADDLIELF 450
    EIFAAPDSLL FGFKEIGDLI AARRKSSLQN STFARTSNYL THPVFNRYHS 500
    ETELLRYLHK LESKDLSLTT SMIPLGSCTM KLNATAEMIP VTWEEFGKIH 550
    PFAPASQTQG YQILFQQLEA WLAEITGFAG ISLQPNAGSQ GEYAGLLVIR 600
    QYHENRGEAH RNVCLIPTSA HGTNPASAVM CGMKVVAVAC DSQGNIDVDD 650
    LKAKAEKHSH ELAALMVTYP STHGVFEEPI QEICAVVHSH GGQVYMDGAN 700
    MNAQVGICRP GDIGADVCHL NLHKTFCIPH GGGGPGMGPI GVASHLVPFL 750
    PGHPVVTIND STQHSHIGAV AAAPWGSASI LVISWMYIAM MGADGLTQAT 800
    KVAILNANYI AKKLESYYPV LYQGKNGLVA HECILDLRSL KKSAAIEIDD 850
    VAKRLMDYGF HAPTVSWPVG GTIMVEPTES ESKQELDRFC DALIAIRQEI 900
    AEIEVGKVDA QDNVLKNAPH TAESLITGEW QHPYSREQAA YPAPWTREYK 950
    FWPAVGRIDA AFGDRNFVCS CLPMDAYSS 979
    Length:979
    Mass (Da):106,853
    Last modified:June 10, 2008 - v1
    Checksum:i7D692D6F2AE0E4E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82139.1.
    RefSeqiYP_001867082.1. NC_010628.1.

    Genome annotation databases

    EnsemblBacteriaiACC82139; ACC82139; Npun_R3754.
    GeneIDi6253099.
    KEGGinpu:Npun_R3754.
    PATRICi22760492. VBINosPun48114_4406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82139.1 .
    RefSeqi YP_001867082.1. NC_010628.1.

    3D structure databases

    ProteinModelPortali B2J427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 63737.Npun_R3754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC82139 ; ACC82139 ; Npun_R3754 .
    GeneIDi 6253099.
    KEGGi npu:Npun_R3754.
    PATRICi 22760492. VBINosPun48114_4406.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.
    PhylomeDBi B2J427.

    Enzyme and pathway databases

    BioCyci NPUN63737:GJNP-3623-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29133 / PCC 73102.

    Entry informationi

    Entry nameiGCSP_NOSP7
    AccessioniPrimary (citable) accession number: B2J427
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3