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B2J427

- GCSP_NOSP7

UniProt

B2J427 - GCSP_NOSP7

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Npun_R3754
Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-3623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Npun_R3754
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei724 – 7241N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi63737.Npun_R3754.

Structurei

3D structure databases

ProteinModelPortaliB2J427.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.
PhylomeDBiB2J427.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2J427-1 [UniParc]FASTAAdd to Basket

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MVLNAPILKS NEQQVLNQKS QKLSSFAPRH IGPNSDDIQQ MLKVLGFPSL    50
DALIDKTVPQ TIRLKQPLKL PEAESEYAAL ASLKKIAAKN QVFRSYIGMG 100
YYDTITPLVI GRNILENPGW YTAYTPYQPE IAQGRLEALL NFQTLIIDLT 150
GLEIANASLL DEATAAAEAM SLSYGVSKNQ ANAYFVSHDC HPQTIDVLQT 200
RAKPLGINII VGDHQTFDFD RAIFGAVLQY PASDGTIYDY RAFIEKAHAK 250
GALVTVAADP LSLTLLTPPG EFGADIAVGS TQRFGIPLGF GGPHAAYFAT 300
KEEYKRLVPG RIVGVSKDAQ GKPALRLALQ TREQHIRREK ATSNICTAQV 350
LLAVMASMYA VYHGPDGLKQ IAENIHQLTL MLAAGLKHLG YKISSEHFFD 400
TLRVELGTRS LEVILEACQA RNINLRIFDD TAVGISVDET TTADDLIELF 450
EIFAAPDSLL FGFKEIGDLI AARRKSSLQN STFARTSNYL THPVFNRYHS 500
ETELLRYLHK LESKDLSLTT SMIPLGSCTM KLNATAEMIP VTWEEFGKIH 550
PFAPASQTQG YQILFQQLEA WLAEITGFAG ISLQPNAGSQ GEYAGLLVIR 600
QYHENRGEAH RNVCLIPTSA HGTNPASAVM CGMKVVAVAC DSQGNIDVDD 650
LKAKAEKHSH ELAALMVTYP STHGVFEEPI QEICAVVHSH GGQVYMDGAN 700
MNAQVGICRP GDIGADVCHL NLHKTFCIPH GGGGPGMGPI GVASHLVPFL 750
PGHPVVTIND STQHSHIGAV AAAPWGSASI LVISWMYIAM MGADGLTQAT 800
KVAILNANYI AKKLESYYPV LYQGKNGLVA HECILDLRSL KKSAAIEIDD 850
VAKRLMDYGF HAPTVSWPVG GTIMVEPTES ESKQELDRFC DALIAIRQEI 900
AEIEVGKVDA QDNVLKNAPH TAESLITGEW QHPYSREQAA YPAPWTREYK 950
FWPAVGRIDA AFGDRNFVCS CLPMDAYSS 979
Length:979
Mass (Da):106,853
Last modified:June 10, 2008 - v1
Checksum:i7D692D6F2AE0E4E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82139.1.
RefSeqiYP_001867082.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82139; ACC82139; Npun_R3754.
GeneIDi6253099.
KEGGinpu:Npun_R3754.
PATRICi22760492. VBINosPun48114_4406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82139.1 .
RefSeqi YP_001867082.1. NC_010628.1.

3D structure databases

ProteinModelPortali B2J427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 63737.Npun_R3754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC82139 ; ACC82139 ; Npun_R3754 .
GeneIDi 6253099.
KEGGi npu:Npun_R3754.
PATRICi 22760492. VBINosPun48114_4406.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.
PhylomeDBi B2J427.

Enzyme and pathway databases

BioCyci NPUN63737:GJNP-3623-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiGCSP_NOSP7
AccessioniPrimary (citable) accession number: B2J427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi