Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2J427 (GCSP_NOSP7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Npun_R3754
OrganismNostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]
Taxonomic identifier63737 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length979 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 979979Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132445

Amino acid modifications

Modified residue7241N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2J427 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 7D692D6F2AE0E4E9

FASTA979106,853
        10         20         30         40         50         60 
MVLNAPILKS NEQQVLNQKS QKLSSFAPRH IGPNSDDIQQ MLKVLGFPSL DALIDKTVPQ 

        70         80         90        100        110        120 
TIRLKQPLKL PEAESEYAAL ASLKKIAAKN QVFRSYIGMG YYDTITPLVI GRNILENPGW 

       130        140        150        160        170        180 
YTAYTPYQPE IAQGRLEALL NFQTLIIDLT GLEIANASLL DEATAAAEAM SLSYGVSKNQ 

       190        200        210        220        230        240 
ANAYFVSHDC HPQTIDVLQT RAKPLGINII VGDHQTFDFD RAIFGAVLQY PASDGTIYDY 

       250        260        270        280        290        300 
RAFIEKAHAK GALVTVAADP LSLTLLTPPG EFGADIAVGS TQRFGIPLGF GGPHAAYFAT 

       310        320        330        340        350        360 
KEEYKRLVPG RIVGVSKDAQ GKPALRLALQ TREQHIRREK ATSNICTAQV LLAVMASMYA 

       370        380        390        400        410        420 
VYHGPDGLKQ IAENIHQLTL MLAAGLKHLG YKISSEHFFD TLRVELGTRS LEVILEACQA 

       430        440        450        460        470        480 
RNINLRIFDD TAVGISVDET TTADDLIELF EIFAAPDSLL FGFKEIGDLI AARRKSSLQN 

       490        500        510        520        530        540 
STFARTSNYL THPVFNRYHS ETELLRYLHK LESKDLSLTT SMIPLGSCTM KLNATAEMIP 

       550        560        570        580        590        600 
VTWEEFGKIH PFAPASQTQG YQILFQQLEA WLAEITGFAG ISLQPNAGSQ GEYAGLLVIR 

       610        620        630        640        650        660 
QYHENRGEAH RNVCLIPTSA HGTNPASAVM CGMKVVAVAC DSQGNIDVDD LKAKAEKHSH 

       670        680        690        700        710        720 
ELAALMVTYP STHGVFEEPI QEICAVVHSH GGQVYMDGAN MNAQVGICRP GDIGADVCHL 

       730        740        750        760        770        780 
NLHKTFCIPH GGGGPGMGPI GVASHLVPFL PGHPVVTIND STQHSHIGAV AAAPWGSASI 

       790        800        810        820        830        840 
LVISWMYIAM MGADGLTQAT KVAILNANYI AKKLESYYPV LYQGKNGLVA HECILDLRSL 

       850        860        870        880        890        900 
KKSAAIEIDD VAKRLMDYGF HAPTVSWPVG GTIMVEPTES ESKQELDRFC DALIAIRQEI 

       910        920        930        940        950        960 
AEIEVGKVDA QDNVLKNAPH TAESLITGEW QHPYSREQAA YPAPWTREYK FWPAVGRIDA 

       970 
AFGDRNFVCS CLPMDAYSS 

« Hide

References

[1]"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. expand/collapse author list , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001037 Genomic DNA. Translation: ACC82139.1.
RefSeqYP_001867082.1. NC_010628.1.

3D structure databases

ProteinModelPortalB2J427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING63737.Npun_R3754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC82139; ACC82139; Npun_R3754.
GeneID6253099.
KEGGnpu:Npun_R3754.
PATRIC22760492. VBINosPun48114_4406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycNPUN63737:GJNP-3623-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NOSP7
AccessionPrimary (citable) accession number: B2J427
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families