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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi496MagnesiumUniRule annotation1
Metal bindingi502MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciNPUN63737:G1GBR-3704-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Npun_R3625
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000001191 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001924761 – 718Polyribonucleotide nucleotidyltransferaseAdd BLAST718

Proteomic databases

PRIDEiB2J2V3

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_R3625

Structurei

3D structure databases

ProteinModelPortaliB2J2V3
SMRiB2J2V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini563 – 622KHUniRule annotationAdd BLAST60
Domaini632 – 700S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0
PhylomeDBiB2J2V3

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B2J2V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVDKSISF DGRDIRLKVG LLAPQAGGSV LIESGDTSVL VTATRSQARE
60 70 80 90 100
GIDFLPLTVD YEERLYAAGR IPGGIMRREG RPPEKTILTS RLIDRPMRPL
110 120 130 140 150
FPSWLRDDLQ IIALTLSMDE LVPPDVLAVT GASIATLIAQ IPFNGPMAAV
160 170 180 190 200
RVGLVGDDFI INPTYAEIEA GDLDLVVAGS PHGVIMVEAG ANQLPERDII
210 220 230 240 250
EAIDFGYEAV RDLIKAQQDL VAELGLVIVQ EAPPEVDQTL ENYIRDRASG
260 270 280 290 300
QIKKILSQFT FTKPERDAAL DVVKDEIATT IKELPEEDPI RVAATANNKA
310 320 330 340 350
LGNTFKDITK YFMRRQIIED NVRVDGRKLD EVRRVSCLVG VLPKRVHGSG
360 370 380 390 400
LFNRELTQVL STCTLGTPGD AQNLNDDMQL DQHKRYLHHY NFPPFSVGET
410 420 430 440 450
KPMRSPGRRE IGHGALAERS LIPVLPSKEQ FPYVIRIVSE VLSSNGSTSM
460 470 480 490 500
GSVCGSTLAL MDAGVPILKP VSGAAMGLIK DGDEVRILTD IQGIEDFLGD
510 520 530 540 550
MDFKVAGTDT GITALQMDMK IPGLSLDVIS QAVHQAKAAR LHILEKMLAC
560 570 580 590 600
IDTPRIETSP YAPRLLTIKI DSDMIGLVIG PGGKTIKGIT EETGAKIDIE
610 620 630 640 650
DDGTVTISAV DENKAKRARN IIQGMTRKLH EGDVYAGRIT RIIPIGAFVE
660 670 680 690 700
FLPGKEGMIH ISQLADYRVG KVEDEVAVGD EVIIKVREID NKGRINLTRL
710
GIHPDQAAAA REAAAVNR
Length:718
Mass (Da):78,160
Last modified:June 10, 2008 - v1
Checksum:iA4155FFDB92CCD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001037 Genomic DNA Translation: ACC82020.1
RefSeqiWP_012409992.1, NC_010628.1

Genome annotation databases

EnsemblBacteriaiACC82020; ACC82020; Npun_R3625
KEGGinpu:Npun_R3625

Similar proteinsi

Entry informationi

Entry nameiPNP_NOSP7
AccessioniPrimary (citable) accession number: B2J2V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health