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B2J075 (B2J075_NOSP7) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH HAMAP-Rule MF_01458
Ordered Locus Names:Npun_F4881 EMBL ACC83227.1
OrganismNostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP] EMBL ACC83227.1
Taxonomic identifier63737 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc ›

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cellular thylakoid membrane; Multi-pass membrane protein; Stromal side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Topological domain1 – 66Cytoplasmic By similarity HAMAP-Rule MF_01458
Transmembrane7 – 2721Helical; By similarity HAMAP-Rule MF_01458
Topological domain28 – 10578Lumenal By similarity HAMAP-Rule MF_01458
Transmembrane106 – 12621Helical; By similarity HAMAP-Rule MF_01458
Topological domain127 – 613487Cytoplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding198 – 2058ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4211 By similarity HAMAP-Rule MF_01458
Metal binding4201Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4241Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding5011Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
B2J075 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 6B0D956E401A7645

FASTA61367,251
        10         20         30         40         50         60 
MNKRWRNAGL YALLFIVVIA LGTAFFDKQP QSRETWRYSR FIQEVQQGRV EKVSLSADRS 

        70         80         90        100        110        120 
TALVTPKYDP AKRIVTLVND PDLINTLTSK GVDISVLPQT DEGFWFKALS SLFFPVLLLV 

       130        140        150        160        170        180 
GLFFLLRRAQ SGPGSQAMNF GKSKARVQME PQTQVTFGDV AGIDQAKLEL NEVVDFLKNA 

       190        200        210        220        230        240 
DRFTAVGAKI PKGVLLVGPP GTGKTLLARA VAGEAGVPFF SISGSEFVEM FVGVGASRVR 

       250        260        270        280        290        300 
DLFEQAKTNA PCIVFIDEID AVGRQRGAGL GGGNDEREQT LNQLLTEMDG FEGNTGIIII 

       310        320        330        340        350        360 
AATNRPDVLD AALLRPGRFD RQVVVDRPDY AGRSEILKVH ARGKTLAKDV DLDKIARRTP 

       370        380        390        400        410        420 
GFTGADLSNL LNEAAILAAR RNLTEISMDE INDAIDRVLA GPEKKDRVMS EKRKTLVAYH 

       430        440        450        460        470        480 
EAGHALVGAL MPDYDPVQKI SIIPRGRAGG LTWFTPSEDR MDTGLYSRAY LENQMAVALG 

       490        500        510        520        530        540 
GRIAEELIFG EEEVTTGASN DLQQVARVAR QMITRFGMSD RLGPVALGRQ QGNMFLGRDI 

       550        560        570        580        590        600 
MSERDFSEET AAAIDEEVRK LVDVAYTRAK EVLVGNRHIL DQIAQMLVEK ETVDAEELQE 

       610 
ILSNNDVTTA AFA

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References

[1]"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. expand/collapse author list , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001037 Genomic DNA. Translation: ACC83227.1.
RefSeqYP_001868170.1. NC_010628.1.

3D structure databases

ProteinModelPortalB2J075.
ModBaseSearch...

Protein-protein interaction databases

STRING63737.Npun_F4881.

Protein family/group databases

MEROPSM41.005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC83227; ACC83227; Npun_F4881.
GeneID6254231.
KEGGnpu:Npun_F4881.
PATRIC22763122. VBINosPun48114_5707.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0465.
HOGENOMHOG000217276.
KOK03798.
OMAGGNPAMN.
ProtClustDBCLSK892632.

Enzyme and pathway databases

BioCycNPUN63737:GJNP-4755-MONOMER.

Family and domain databases

HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2J075_NOSP7
AccessionPrimary (citable) accession number: B2J075
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info