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B2IX54

- PUR9_NOSP7

UniProt

B2IX54 - PUR9_NOSP7

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Npun_R6316
Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-6182-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Npun_R6316
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096077Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_R6316.

Structurei

3D structure databases

ProteinModelPortaliB2IX54.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiLKSTLRY.
OrthoDBiEOG6QCDFF.
PhylomeDBiB2IX54.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2IX54-1 [UniParc]FASTAAdd to Basket

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MARLALLSVS NKTGIIDLAR SLVEEFDFDL ISSGGTAQAL KDAGLPVTKV    50
ADYTGSPEIL GGRVKTLHPR IHGGILARRD VPQDITDLEN NQIRPIDLVV 100
VNLYPFEETI AKPGVTLLEA VEQIDIGGPA MLRASSKNFA HLAVLCDPAQ 150
YDEYLEELRQ NNGVASLEFR QKAALKGFSH TASYDQAIAQ ALTCQFASYL 200
ADTQQYTLSG TQLQSLRYGE NPHQPATWYQ TGTTPTGWAA ATKLQGKELS 250
YNNLVDLEAA RRIIAEFTDT PAATIIKHTN PCGTALGSSI SEAYKKAFNA 300
DSTSAFGGIV ALNRPIDAAT ASELTKTFLE CVVAPSCEAE AQEILAKKSN 350
VRVLTLADLS SGPKDTVKAI AGGFLVQTAD DIVADTSQWQ VVTERQPTDS 400
ELAELLFAWK VCKHVKSNAI VVTSDRTTLG VGAGQMNRVG SVKIALEQAG 450
EKAKGAILAS DGFFPFDDSV RTAAAAGITA IVQPGGSLRD KDSIKAANDL 500
GLLMVLTGVR HFLH 514
Length:514
Mass (Da):54,873
Last modified:June 10, 2008 - v1
Checksum:iD25BFB75E9D5654D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC84589.1.
RefSeqiYP_001869532.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC84589; ACC84589; Npun_R6316.
GeneIDi6255660.
KEGGinpu:Npun_R6316.
PATRICi22766575. VBINosPun48114_7409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC84589.1 .
RefSeqi YP_001869532.1. NC_010628.1.

3D structure databases

ProteinModelPortali B2IX54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 63737.Npun_R6316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC84589 ; ACC84589 ; Npun_R6316 .
GeneIDi 6255660.
KEGGi npu:Npun_R6316.
PATRICi 22766575. VBINosPun48114_7409.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi LKSTLRY.
OrthoDBi EOG6QCDFF.
PhylomeDBi B2IX54.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci NPUN63737:GJNP-6182-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiPUR9_NOSP7
AccessioniPrimary (citable) accession number: B2IX54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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