B2IWK6 (LPXC_NOSP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	Npun_F2929

Organism

Nostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]

Taxonomic identifier

63737 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388		PRO_1000122802

Sequences

	Sequence		Length	Mass (Da)
	B2IWK6 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 3429FEBE3CAFF6F3	FASTA	292	31,710
	10 20 30 40 50 60 MQQHTLAAEI TQVGVGLHSG VNTQVRILPD ETGSGRYFVR VDLPDLPIIP AQVAAVSHTV 70 80 90 100 110 120 LSTQLGKGEV YVRTVEHLLA ALSGMGVDNA RIEIDGSEVP LLDGSASVWV ANIAQVGLVS 130 140 150 160 170 180 QPVNNQVPLT VTEPIWVYQG DAFVCALPAP ETRFSYGIEF DLPAIGNQWY SWSLTTELEK 190 200 210 220 230 240 ASASFAAEIA PARTFGLLHQ IEHLQKTGLI KGGSLDNALV CGPEGWLNPP LRFANEPVRH 250 260 270 280 290 KILDLVGDLS LLGAFPRAHF LAYKASHNLH IQLAQKILDF GFDFAQSNDF RF

References

[1]

"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001037 Genomic DNA. Translation: ACC81460.1.
RefSeq	YP_001866403.1. NC_010628.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2IWK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6252340.
GenomeReviews	Gene locus Npun_F2929 in contig CP001037_GR.
KEGG	npu:Npun_F2929.
PATRIC	22758528. VBINosPun48114_3429.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	B2IWK6.
ProtClustDB	PRK13186.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_NOSP7

Accession

Primary (citable) accession number: B2IWK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program