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B2IUQ9

- B2IUQ9_NOSP7

UniProt

B2IUQ9 - B2IUQ9_NOSP7

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Protein
Non-canonical purine NTP pyrophosphatase
Gene
Npun_R4467
Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotationSAAS annotations

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Magnesium or manganese By similarityUniRule annotation
Metal bindingi68 – 681Magnesium or manganese By similarityUniRule annotation
Binding sitei150 – 1501Substrate By similarityUniRule annotation
Binding sitei170 – 1701Substrate By similarityUniRule annotation
Binding sitei176 – 1761Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Nucleotide metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-4341-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Gene namesi
Ordered Locus Names:Npun_R4467Imported
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)Imported
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi63737.Npun_R4467.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 146Substrate binding By similarityUniRule annotation
Regioni68 – 692Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiDHNDAAN.
OrthoDBiEOG6CZQQP.
PhylomeDBiB2IUQ9.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

B2IUQ9-1 [UniParc]FASTAAdd to Basket

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MTKLLVVATG NPGKLREMQA YLKNSGWELT LKPEELDIEE TGETFAANAC    50
LKASQIAKAT GNWAIADDSG LQVDALNGAP GVYSARYAKT DSERIARLLK 100
ELGNEVNRQA QFVCAVAIAR PDGAIVLESE GICRGEILHA PRGDSGFGYD 150
PIFYVQELQL TFAEMTRELK GSISHRGKAF TALLPQLERI KRRD 194
Length:194
Mass (Da):21,225
Last modified:June 10, 2008 - v1
Checksum:iEDA708B3CBC12B0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82834.1.
RefSeqiYP_001867777.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82834; ACC82834; Npun_R4467.
GeneIDi6253817.
KEGGinpu:Npun_R4467.
PATRICi22762171. VBINosPun48114_5237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001037 Genomic DNA. Translation: ACC82834.1 .
RefSeqi YP_001867777.1. NC_010628.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 63737.Npun_R4467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC82834 ; ACC82834 ; Npun_R4467 .
GeneIDi 6253817.
KEGGi npu:Npun_R4467.
PATRICi 22762171. VBINosPun48114_5237.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi DHNDAAN.
OrthoDBi EOG6CZQQP.
PhylomeDBi B2IUQ9.

Enzyme and pathway databases

BioCyci NPUN63737:GJNP-4341-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiB2IUQ9_NOSP7
AccessioniPrimary (citable) accession number: B2IUQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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