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B2IUQ9 (B2IUQ9_NOSP7) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405

EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Ordered Locus Names:Npun_R4467 EMBL ACC82834.1
OrganismNostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP] EMBL ACC82834.1
Taxonomic identifier63737 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS002637

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region9 – 146Substrate binding By similarity HAMAP-Rule MF_01405
Region68 – 692Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding391Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding681Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1501Substrate By similarity HAMAP-Rule MF_01405
Binding site1701Substrate By similarity HAMAP-Rule MF_01405
Binding site1761Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
B2IUQ9 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: EDA708B3CBC12B0A

FASTA19421,225
        10         20         30         40         50         60 
MTKLLVVATG NPGKLREMQA YLKNSGWELT LKPEELDIEE TGETFAANAC LKASQIAKAT 

        70         80         90        100        110        120 
GNWAIADDSG LQVDALNGAP GVYSARYAKT DSERIARLLK ELGNEVNRQA QFVCAVAIAR 

       130        140        150        160        170        180 
PDGAIVLESE GICRGEILHA PRGDSGFGYD PIFYVQELQL TFAEMTRELK GSISHRGKAF 

       190 
TALLPQLERI KRRD 

« Hide

References

[1]"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. expand/collapse author list , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001037 Genomic DNA. Translation: ACC82834.1.
RefSeqYP_001867777.1. NC_010628.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING63737.Npun_R4467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC82834; ACC82834; Npun_R4467.
GeneID6253817.
KEGGnpu:Npun_R4467.
PATRIC22762171. VBINosPun48114_5237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OMAGEAHNDA.
OrthoDBEOG6CZQQP.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycNPUN63737:GJNP-4341-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2IUQ9_NOSP7
AccessionPrimary (citable) accession number: B2IUQ9
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)