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B2IUQ9

- B2IUQ9_NOSP7

UniProt

B2IUQ9 - B2IUQ9_NOSP7

Protein

Non-canonical purine NTP pyrophosphatase

Gene

Npun_R4467

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Magnesium or manganeseUniRule annotation
    Metal bindingi68 – 681Magnesium or manganeseUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Nucleotide metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNPUN63737:GJNP-4341-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Gene namesi
    Ordered Locus Names:Npun_R4467Imported
    OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)Imported
    Taxonomic identifieri63737 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000001191: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi63737.Npun_R4467.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 146Substrate bindingUniRule annotation
    Regioni68 – 692Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiDHNDAAN.
    OrthoDBiEOG6CZQQP.
    PhylomeDBiB2IUQ9.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.
    TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2IUQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLLVVATG NPGKLREMQA YLKNSGWELT LKPEELDIEE TGETFAANAC    50
    LKASQIAKAT GNWAIADDSG LQVDALNGAP GVYSARYAKT DSERIARLLK 100
    ELGNEVNRQA QFVCAVAIAR PDGAIVLESE GICRGEILHA PRGDSGFGYD 150
    PIFYVQELQL TFAEMTRELK GSISHRGKAF TALLPQLERI KRRD 194
    Length:194
    Mass (Da):21,225
    Last modified:June 10, 2008 - v1
    Checksum:iEDA708B3CBC12B0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82834.1.
    RefSeqiYP_001867777.1. NC_010628.1.

    Genome annotation databases

    EnsemblBacteriaiACC82834; ACC82834; Npun_R4467.
    GeneIDi6253817.
    KEGGinpu:Npun_R4467.
    PATRICi22762171. VBINosPun48114_5237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001037 Genomic DNA. Translation: ACC82834.1 .
    RefSeqi YP_001867777.1. NC_010628.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 63737.Npun_R4467.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC82834 ; ACC82834 ; Npun_R4467 .
    GeneIDi 6253817.
    KEGGi npu:Npun_R4467.
    PATRICi 22762171. VBINosPun48114_5237.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi DHNDAAN.
    OrthoDBi EOG6CZQQP.
    PhylomeDBi B2IUQ9.

    Enzyme and pathway databases

    BioCyci NPUN63737:GJNP-4341-MONOMER.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29133 / PCC 73102Imported.

    Entry informationi

    Entry nameiB2IUQ9_NOSP7
    AccessioniPrimary (citable) accession number: B2IUQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3