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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei79 – 791Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei87 – 871PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi91 – 911Magnesium 1UniRule annotation
Binding sitei110 – 1101Anthranilate 1UniRule annotation
Binding sitei119 – 1191Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei165 – 1651Anthranilate 2UniRule annotation
Metal bindingi224 – 2241Magnesium 2UniRule annotation
Metal bindingi225 – 2251Magnesium 1UniRule annotation
Metal bindingi225 – 2251Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSPNE516950:GI38-1813-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:SPCG_1799
OrganismiStreptococcus pneumoniae (strain CGSP14)
Taxonomic identifieri516950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001682 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Anthranilate phosphoribosyltransferasePRO_1000099851Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2ISS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni89 – 924Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni107 – 1159Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

B2ISS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEIIEKLAK FENLSGVEMT DVIERIVTGR VTEAQIASLL LALKMKGETP
60 70 80 90 100
EERTAIAQVM RGHAQHIPTE IHDAMDNCGT GGDKSFSFNI STTAAFVLAG
110 120 130 140 150
GGIHMAKHGN RSISSKSGSA DVLEALGINL DLKPAELGKV FDKTGIVFLF
160 170 180 190 200
AKNMHPAMKY IMPARLELGI PTIMNLTGPL IHPMALETQL LGISRPELLE
210 220 230 240 250
STAQVLKNMG RKRAIVVAGP EGLDEAGLNG TTKIALLENG EISLSSFTPE
260 270 280 290 300
DLGMEGYAME DIRGGNAQEN AEILLSVLKN EASPFLETTV LNAGLGFYAN
310 320 330
GKIDSIKEGV ALARQVIARG KALEKLRLLQ EYQK
Length:334
Mass (Da):35,905
Last modified:June 10, 2008 - v1
Checksum:iB90274495CA4D21C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB91051.1.
RefSeqiWP_000658684.1. NC_010582.1.

Genome annotation databases

EnsemblBacteriaiACB91051; ACB91051; SPCG_1799.
KEGGispw:SPCG_1799.
PATRICi19679937. VBIStrPne123335_1925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB91051.1.
RefSeqiWP_000658684.1. NC_010582.1.

3D structure databases

ProteinModelPortaliB2ISS4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB91051; ACB91051; SPCG_1799.
KEGGispw:SPCG_1799.
PATRICi19679937. VBIStrPne123335_1925.

Phylogenomic databases

HOGENOMiHOG000230451.
KOiK00766.
OMAiHSGQAYQ.
OrthoDBiEOG6D5G6B.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciSPNE516950:GI38-1813-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
    Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
    BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGSP14.

Entry informationi

Entry nameiTRPD_STRPS
AccessioniPrimary (citable) accession number: B2ISS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.