B2ISS3 (TRPC_STRPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SPCG_1798

Organism

Streptococcus pneumoniae (strain CGSP14) [Complete proteome] [HAMAP]

Taxonomic identifier

516950 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095899

Sequences

	Sequence		Length	Mass (Da)
	B2ISS3 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 8A13FBEE27A2D85C	FASTA	255	28,940
	10 20 30 40 50 60 MSQEFLARIL EQKAREVEQM KLEQIQPLRQ TYRLAEFLKN HQDRLQVIAE VKKASPSLGD 70 80 90 100 110 120 INLDVDIVQQ AQTYEENGAV MISVLTDEVF FKGHLDYLRE ISSQVEIPTL NKDFIIDEKQ 130 140 150 160 170 180 IIRARNAGAT VILLIVAALS EERLKELYDY ATELGLEVLV ETHNLAELEV AHRLGAEIIG 190 200 210 220 230 240 VNNRNLTTFE VDLQTSVDLA PYFEEGRYYI SESAIFTGQD AERLAPYFNG ILVGTALMQA 250 ENVAQRIKEL QIDKG

References

[1]

"Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14." Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H. BMC Genomics 10:158-158(2009) [PubMed: 19361343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CGSP14.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001033 Genomic DNA. Translation: ACB91050.1.
RefSeq	YP_001836515.1. NC_010582.1.
3D structure databases
ProteinModelPortal	B2ISS3.
ModBase	Search...
Protein-protein interaction databases
STRING	B2ISS3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000016547; EBSTRP00000015861; EBSTRG00000016547.
GeneID	6218293.
GenomeReviews	Gene locus SPCG_1798 in contig CP001033_GR.
KEGG	spw:SPCG_1798.
PATRIC	19679935. VBIStrPne123335_1924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRPS

Accession

Primary (citable) accession number: B2ISS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program