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B2IRV5 (B2IRV5_STRPS) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361
Gene names
Name:aroF EMBL ACB90924.1
Ordered Locus Names:SPCG_1672
OrganismStreptococcus pneumoniae (strain CGSP14) [Complete proteome] [HAMAP]
Taxonomic identifier516950 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361

Catalytic activity

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361

Sequence similarities

Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Sequences

Sequence LengthMass (Da)Tools
B2IRV5 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 573CC7A258BD71ED

FASTA34338,725
        10         20         30         40         50         60 
MAFIEKGQEI DMEVIKAETQ LSAEALRLKE SRDRELADII SGEDDRILLV IGPCSSDNEE 

        70         80         90        100        110        120 
AVLEYARRLS ALQKKVADKI FMVMRVYTAK PRTNGDGYKG LVHQPDTSKA PSLINGLQAV 

       130        140        150        160        170        180 
RQLHYRVITE TGLTTADEML YPSNLILVDD LVSYHAVGAR SVEDQEHRFV ASGIDAPVGM 

       190        200        210        220        230        240 
KNPTSGNLGV MFNAIYAAQN KQTFLYHGQE VETSGNPLAH VILRGAVNEY GNYMPNYYYE 

       250        260        270        280        290        300 
NLLQAIERYE TMGLENPFIL IDTNHDNSGK QYMEQIRIVR QTLQNRDWNE KIKKTVRGFM 

       310        320        330        340 
IESYLADGRQ NQPEIFGCSI TDPCLGWENT EALVEEIYAT LTK

« Hide

References

[1]"Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
BMC Genomics 10:158-158(2009) [PubMed: 19361343] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001033 Genomic DNA. Translation: ACB90924.1.
RefSeqYP_001836389.1. NC_010582.1.

3D structure databases

ProteinModelPortalB2IRV5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2IRV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000018554; EBSTRP00000017868; EBSTRG00000018554.
GeneID6218597.
GenomeReviewsGene locus SPCG_1672 in contig CP001033_GR.
KEGGspw:SPCG_1672.
PATRIC19679662. VBIStrPne123335_1788.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000028141.
HOGENOMHBG670536.
OMAELFIVMR.
ProtClustDBPRK09261.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01626.
PANTHERPTHR21225. AroFGH. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsTIGR00034. AroFGH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2IRV5_STRPS
AccessionPrimary (citable) accession number: B2IRV5
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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