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B2IRV3

- B2IRV3_STRPS

UniProt

B2IRV3 - B2IRV3_STRPS

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Protein
Alanine racemase
Gene
alr, SPCG_1670
Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSPNE516950:GI38-1683-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SPCG_1670Imported
OrganismiStreptococcus pneumoniae (strain CGSP14)Imported
Taxonomic identifieri516950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001682: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi516950.SPCG_1670.

Structurei

3D structure databases

ProteinModelPortaliB2IRV3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2IRV3-1 [UniParc]FASTAAdd to Basket

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MSFWRKIMKA SPHRPTKALI HLGAIRQNIQ QMGAHIPQGT LKWAVVKANA    50
YGHGAVAVAK AIQDDVDGFC VSNIDEAIEL RQAGLSKPIL ILGVSEIEAV 100
ALAKEYDFTL TVAGLEWIQA LLDKEVDLTG LTVHLKIDSG MGRIGFREVS 150
EVEQAQDLLQ KHGVCVEGIF THFATADEES DDYFNAQLER FKTILASMKE 200
VPELVHASNS ATTLWHVETI FNAVRMGDAM YGLNPSGAVL DLPYDLIPAL 250
TLESALVHVK TVPAGACMGY GATYQADSEQ VIATVPIGYA DGWTRDMQNF 300
SVLVDGQACP IVGRVSMDQI TIRLPKLYPL GTKVTLIGSN GDKEITATQV 350
ATYRVTINYE VVCLLSDRIP REYY 374
Length:374
Mass (Da):40,908
Last modified:June 10, 2008 - v1
Checksum:i71B255666051B88F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001033 Genomic DNA. Translation: ACB90922.1.
RefSeqiYP_001836387.1. NC_010582.1.

Genome annotation databases

EnsemblBacteriaiACB90922; ACB90922; SPCG_1670.
GeneIDi6217624.
KEGGispw:SPCG_1670.
PATRICi19679658. VBIStrPne123335_1786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001033 Genomic DNA. Translation: ACB90922.1 .
RefSeqi YP_001836387.1. NC_010582.1.

3D structure databases

ProteinModelPortali B2IRV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 516950.SPCG_1670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB90922 ; ACB90922 ; SPCG_1670 .
GeneIDi 6217624.
KEGGi spw:SPCG_1670.
PATRICi 19679658. VBIStrPne123335_1786.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SPNE516950:GI38-1683-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
    Ding F., Tang P., Hsu M.H., Cui P., Hu S., Yu J., Chiu C.H.
    BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGSP14Imported.

Entry informationi

Entry nameiB2IRV3_STRPS
AccessioniPrimary (citable) accession number: B2IRV3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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