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Protein
Submitted name:

Sialidase A (Neuraminidase A)

Gene

nanA

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSPNE516950:GI38-1678-MONOMER.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase A (Neuraminidase A)Imported
Gene namesi
Name:nanAImported
Ordered Locus Names:SPCG_1665Imported
OrganismiStreptococcus pneumoniae (strain CGSP14)Imported
Taxonomic identifieri516950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001682: Chromosome

Subcellular locationi

Secretedcell wall SAAS annotation; Peptidoglycan-anchor SAAS annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi516950.SPCG_1665.

Structurei

3D structure databases

ProteinModelPortaliB2IRU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000284737.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2IRU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFRNRDID IERISMNRSV QERKCRYSIR KLSVGAVSMI VGAVVFGTSP
60 70 80 90 100
VLAQEGASEQ PLANETQLSG ESSTLTDTEK SQPSSETELS GNKQEQERKD
110 120 130 140 150
KQEEKIPRDY YARDLENVET VIEKEDVETN ASNGQRVDLS SELDKLKKLE
160 170 180 190 200
NATVHMEFKP DAKAPAFYNL FSVSSATKKD EYFTMAVYNN TATLEGRGSD
210 220 230 240 250
GQQFYGNYND APLKVKPGQW NSVTFTVEKP TAELPKGRVR LYVNGVLSRT
260 270 280 290 300
SLKSGNFIKD MPDVTHVQIG ATKRANNTVW GSNLQIQNLT VYNRALTPEE
310 320 330 340 350
VQKRSQLFKR SDLEKKLPEG AVLTEKTDIF ESGRNGKPNK DGIKSYRIPA
360 370 380 390 400
LLKTDKGTLI AGADERRLHS SDWGDIGMVI RRSEDNGKTW GDKVVISNLR
410 420 430 440 450
DNPEAKDPAA PSPLNIDMVL VQDPTTKRIF SIYDMFPEGR AVFGMPKTPE
460 470 480 490 500
KAYEKIGDKT YQILYKQGES GHYTVRENGE VYNAQNQKTD YRVVVNPTEP
510 520 530 540 550
GYRDKGNLYK GQELIGNIYF AHSTKNPFRV ANTSYLWMSY SDDDGKTWSA
560 570 580 590 600
PRDITPGLRK DWMKFLGTGP GTGIVLRNGP HKGRILIPVY TTNNVSHLNG
610 620 630 640 650
SQSSRVIYSD DHGKTWHAGE AVNDNRQVDG QKIHSSTMNN ERAQNTESTV
660 670 680 690 700
VQLNNGDVKL FMRGLTGDLQ VATSKDGGVT WEKDIKRYPQ VKDVYVQMSA
710 720 730 740 750
IHTMHEGKEY IILSNAGGPK RENGMVHLAR VEENGELTWL KHNPIQKGEF
760 770 780 790 800
AYNSLQELGN GEYGILYEHT EKGQNAYTLS FRKFNWDFLS KDLISPTEAK
810 820 830 840 850
VKRTREMGKG EMGKGVIGLE FDSEVLVNKA PTLQLANGKT ATFLTQYDSK
860 870 880 890 900
TLLFAVDKED IGQEIIGIAK GSIESMHNLP VNLAGARVPG GVNGSKAAVH
910 920 930 940 950
EVPEFTGGVN GTEPAVHEIA EYKGSDSLVT LTTKEDYTYK APLAQQALPE
960 970 980
TGNKESDLLA SLGLTAFFLG LFTLGKKREQ
Length:980
Mass (Da):109,129
Last modified:June 10, 2008 - v1
Checksum:i1EB4EDCC0FD82273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB90917.1.
RefSeqiYP_001836382.1. NC_010582.1.

Genome annotation databases

EnsemblBacteriaiACB90917; ACB90917; SPCG_1665.
GeneIDi6217600.
KEGGispw:SPCG_1665.
PATRICi19679644. VBIStrPne123335_1779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB90917.1.
RefSeqiYP_001836382.1. NC_010582.1.

3D structure databases

ProteinModelPortaliB2IRU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi516950.SPCG_1665.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB90917; ACB90917; SPCG_1665.
GeneIDi6217600.
KEGGispw:SPCG_1665.
PATRICi19679644. VBIStrPne123335_1779.

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000284737.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Enzyme and pathway databases

BioCyciSPNE516950:GI38-1678-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
    Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
    BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGSP14Imported.

Entry informationi

Entry nameiB2IRU8_STRPS
AccessioniPrimary (citable) accession number: B2IRU8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.