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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi155 – 162ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:SPCG_0001
OrganismiStreptococcus pneumoniae (strain CGSP14)
Taxonomic identifieri516950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001682 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001220251 – 453Chromosomal replication initiator protein DnaAAdd BLAST453

Structurei

3D structure databases

ProteinModelPortaliB2IQY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiQSKTRKR.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2IQY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKQFWNRI LEFAQERLTR SMYDFYAIQA ELIKVEENVA TIFLPRSEME
60 70 80 90 100
MVWEKQLKDI IVVAGFEIYD AEITPHYIFT KPQDTTSSQV EEATNLTLYD
110 120 130 140 150
YSPKLVSIPY SDTGLKEKYT FDNFIQGDGN VWAVSAALAV SEDLALTYNP
160 170 180 190 200
LFIYGGPGLG KTHLLNAIGN EILKNIPNAR VKYIPAESFI NDFLDHLRLG
210 220 230 240 250
EMEKFKKTYR SLDLLLIDDI QSLSGKKVAT QEEFFNTFNA LHDKQKQIVL
260 270 280 290 300
TSDRSPKHLE GLEERLVTRF SWGLTQTITP PDFETRIAIL QSKTEHLGYN
310 320 330 340 350
FQSDTLEYLA GQFDSNVRDL EGAINDITLI ARVKKIKDIT IDIAAEAIRA
360 370 380 390 400
RKQDVSQMLV IPIDKIQTEV GNFYGVSIKE MKGSRRLQNI VLARQVAMYL
410 420 430 440 450
SRELTDNSLP KIGKEFGGKD HTTVIHAHAK IKSLIDQDDN LRLEIESIKK

KIK
Length:453
Mass (Da):51,782
Last modified:June 10, 2008 - v1
Checksum:iC88BBB813B02ACC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB89253.1.
RefSeqiWP_000660615.1. NC_010582.1.

Genome annotation databases

EnsemblBacteriaiACB89253; ACB89253; SPCG_0001.
KEGGispw:SPCG_0001.
PATRICi19676075. VBIStrPne123335_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB89253.1.
RefSeqiWP_000660615.1. NC_010582.1.

3D structure databases

ProteinModelPortaliB2IQY9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB89253; ACB89253; SPCG_0001.
KEGGispw:SPCG_0001.
PATRICi19676075. VBIStrPne123335_0001.

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiQSKTRKR.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_STRPS
AccessioniPrimary (citable) accession number: B2IQY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.