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B2IQS1 (DEF_STRPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide deformylase
Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:SPCG_1443
OrganismStreptococcus pneumoniae (strain CGSP14) [Complete proteome] [HAMAP]
Taxonomic identifier516950 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtranslation

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Peptide deformylase HAMAP MF_00163
PRO_1000097350

Sites

Active site1741 By similarity
Metal binding1301Iron By similarity
Metal binding1731Iron By similarity
Metal binding1771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2IQS1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: E332956982A67161

FASTA20322,692
        10         20         30         40         50         60 
MSAIERITKA AHLIDMNDII REGNPTLRTV AEEVTFPLSD QEIILGEKMM QFLKHSQDPV 

        70         80         90        100        110        120 
MAEKMGLRGG VGLAAPQLDI SKRIIAVLVP NIVEEGETPQ EAYDLEAIMY NPKIVSHSVQ 

       130        140        150        160        170        180 
DAALGEGEGC LSVDRNVPGY VVRHARVTVD YFDKDGEKHR IKLKGYNSIV VQHEIDHING 

       190        200 
IMFYDRINEK DPFAVKDGLL ILE

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References

[1]"Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
BMC Genomics 10:158-158(2009) [PubMed: 19361343] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CGSP14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001033 Genomic DNA. Translation: ACB90695.1.
RefSeqYP_001836160.1. NC_010582.1.

3D structure databases

ProteinModelPortalB2IQS1.
SMRB2IQS1. Positions 2-203.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2IQS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000018150; EBSTRP00000017464; EBSTRG00000018150.
GeneID6217864.
GenomeReviewsGene locus SPCG_1443 in contig CP001033_GR.
KEGGspw:SPCG_1443.
PATRIC19679172. VBIStrPne123335_1542.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000026595.
HOGENOMHBG665227.
OMAADGEGCL.
ProtClustDBPRK00150.

Family and domain databases

HAMAPMF_00163. Pep_deformylase.
[Tree]
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
Gene3DG3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KOK01462.
PANTHERPTHR10458. Fmet_deformylase. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. Fmet_deformylase. 1 hit.
TIGRFAMsTIGR00079. Pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_STRPS
AccessionPrimary (citable) accession number: B2IQS1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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