B2IPU2 (B2IPU2_STRPS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phospho-beta-galactosidase HAMAP MF_01574 RuleBase RU004469
EC=3.2.1.85 HAMAP MF_01574 RuleBase RU004469

Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase HAMAP MF_01574
P-beta-Gal HAMAP MF_01574

Gene names

Name:	lacG HAMAP MF_01574 EMBL ACB90364.1
Ordered Locus Names:	SPCG_1112

Organism

Streptococcus pneumoniae (strain CGSP14) [Complete proteome] [HAMAP]

Taxonomic identifier

516950 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574 RuleBase RU004469
Pathway	Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574 RuleBase RU004469
Sequence similarities	Belongs to the glycosyl hydrolase 1 family. HAMAP MF_01574 RuleBase RU003690

Ontologies

Keywords
Molecular function	Glycosidase RuleBase RU004468 HAMAP MF_01574 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	6-phospho-beta-galactosidase activity Inferred from electronic annotation. Source: HAMAP cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	163	1	Proton donor By similarity HAMAP MF_01574
	Active site	378	1	Nucleophile By similarity HAMAP MF_01574

Sequences

	Sequence		Length	Mass (Da)
	B2IPU2 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: D45561A1160282E6	FASTA	471	54,290
	10 20 30 40 50 60 MKKMTKTLPK DFIFGGATAA YQAEGATHTD GKGPVAWDKY LEDNYWYTAE PASDFYNRYP 70 80 90 100 110 120 VDLKLAEEYG VNGIRISIAW SRIFPTGYGQ VNAKGVEFYH NLFAECHKRH VEPFVTLHHF 130 140 150 160 170 180 DTPEALHSNG DFLNRENIEH FVDYAAFCFE EFPEVNYWTT FNEIGPIGDG QYLVGKFPPG 190 200 210 220 230 240 IQYDLAKVFQ SHHNMMVSHA RAVKLYKEKG YKGEIGVVHA LPTKYPLDPE NPADVRAAEL 250 260 270 280 290 300 EDIIHNKFIL DATYLGRYSA ETMEGVNHIL SVNGGSLDLR EEDFTALEAA KDLNDFLGIN 310 320 330 340 350 360 YYMSDWMEAF DGETEIIHNG KGEKGSSKYQ IKGVGRRVAP DYVPRTDWDW IIYPQGLYDQ 370 380 390 400 410 420 IMRVKKDYPN YKKIYITENG LGYKDEFVDN TVYDDGRIDY VKQHLEILSD AIADGANVKG 430 440 450 460 470 YFIWSLMDVF SWSNGYEKRY GLFYVDFETQ ERYPKKSAHW YKKVAETQII D

References

[1]

"Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14." Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H. BMC Genomics 10:158-158(2009) [PubMed: 19361343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001033 Genomic DNA. Translation: ACB90364.1.
RefSeq	YP_001835829.1. NC_010582.1.
3D structure databases
ProteinModelPortal	B2IPU2.
ModBase	Search...
Protein-protein interaction databases
STRING	B2IPU2.
Protein family/group databases
CAZy	GH1. Glycoside Hydrolase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000016631; EBSTRP00000015945; EBSTRG00000016631.
GeneID	6218043.
GenomeReviews	Gene locus SPCG_1112 in contig CP001033_GR.
KEGG	spw:SPCG_1112.
PATRIC	19678468. VBIStrPne123335_1190.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027409.
HOGENOM	HBG316462.
OMA	PTGYGEV.
ProtClustDB	PRK13511.
Family and domain databases
HAMAP	MF_01574. LacG. [Tree]
InterPro	IPR005928. 6P-beta-galactosidase. IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K01220.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMs	TIGR01233. LacG. 1 hit.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2IPU2_STRPS

Accession

Primary (citable) accession number: B2IPU2

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)