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Protein

Thymidylate kinase

Gene

tmk

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE516950:GI38-918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:SPCG_0909
OrganismiStreptococcus pneumoniae (strain CGSP14)
Taxonomic identifieri516950 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001682 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Thymidylate kinasePRO_1000097433Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB2IP90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2IP90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGFLVSLE GPEGAGKTSV LEALLPILEE KGVKVLTTRE PGGVLIGEKI
60 70 80 90 100
REVILDPSHT QMDAKTELLL YIASRRQHLV EKVLPALEAG KLVIMDRFID
110 120 130 140 150
SSVAYQGFGR GLDIEAIDWL NQFATDGLKP DLTLYFDIEV EEGLARIAAN
160 170 180 190 200
SDREVNRLDL EGLELHKKVR QGYLSLLEKE GNRIVKIDAS LPLEQVVETT
210
KAVLFDGMDL AK
Length:212
Mass (Da):23,438
Last modified:June 10, 2008 - v1
Checksum:iFFBD42D37EC4273E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB90161.1.
RefSeqiWP_000033390.1. NC_010582.1.

Genome annotation databases

EnsemblBacteriaiACB90161; ACB90161; SPCG_0909.
KEGGispw:SPCG_0909.
PATRICi19678046. VBIStrPne123335_0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA. Translation: ACB90161.1.
RefSeqiWP_000033390.1. NC_010582.1.

3D structure databases

ProteinModelPortaliB2IP90.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB90161; ACB90161; SPCG_0909.
KEGGispw:SPCG_0909.
PATRICi19678046. VBIStrPne123335_0980.

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciSPNE516950:GI38-918-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
    Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
    BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CGSP14.

Entry informationi

Entry nameiKTHY_STRPS
AccessioniPrimary (citable) accession number: B2IP90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: December 9, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.